Postdoctoral Researchers

Dr. Manale Karam

manale Dolbur

 Postdoctoral Researcher

 Tel: + 974 4454 6549
 Email: mdoldur@hbku.edu.qa
BRIEF
BIOGRAPHY
Dr Manale Karam (Doldur) received her B.Sc. degree in Biochemistry from the Holy Spirit University of Kaslik in Lebanon. She completed her M.Sc. degree in Oncology, Pharmacology and Therapeutics and Ph.D. in Cellular and Molecular Biology at the École Normale Supérieure de Cachan and the University of Paris-Sud in France. After obtaining her doctoral degree in 2012, she became a research fellow in the Molecular Oncology and Pharmacology team at the Laboratory of Biology and Applied Pharmacology (LBPA, CNRS) in France. In 2013, she joined the Cancer Research Center at QBRI as a postdoctoral researcher. In addition to her research activities, she has served as a guest lecturer at the Faculty of Medicine of the University of Paris-Sud and the École Normale Supérieure de Cachan in France, where she taught on different topics related to Cancer Biology and Pharmacology as well as Molecular and Cellular Biology. Currently, she is actively participating in teaching activities at Qatar University and Hamad Bin Khalifa University.
RESEARCH
INTEREST
Dr. Karam’s research interest lies in understanding the molecular mechanisms of cancer initiation and progression and developing novel strategies for prevention, diagnosis and treatment. Therefore, her work focuses on studying several cancer-related signaling pathways and biological processes including crosstalks between receptor tyrosine kinase (RTK) pathways, epithelial-mesenchymal transition, tumor growth and metastasis development and resistance to existing treatments, particularly in breast cancer and melanoma. Dr. Karam’s research at QBRI aims at developing new cancer therapies by using pharmacological and cellular strategies. More specifically, her projects focus on:
  • Characterization and evaluation of the anti-tumoral activity of Natural Killer cells differentiated from hematopoietic stem cells
  • Evaluation of the anti-cancer activity of medicinal plants that are unique to Qatar and the region
CURRENT
RESEARCH
PROJECT
Natural Killer (NK) cells are lymphocytes of the innate immune system with potent cytotoxic activity against cancer cells. However, cancer patients often exhibit abnormal NK cell numbers, phenotypes and functions, which allow cancer evasion from NK surveillance. Therefore, appropriate NK cell transfer holds a considerable potential for anti-cancer therapy. Our aim is to produce, in ex vivo cultures, NK cells in optimal quantities and anti-tumoral function for adoptive transfer in cancer patients. Therefore, hematopoietic stem cells (HSCs) are isolated from cord blood and differentiated into NK cells by using a system based on Hoxb4 growth factor delivery in addition to a cocktail of soluble cytokines. The yield and anti-tumoral activity of these HSC-differentiated NK cells will be improved by using different experimentally engineered systems for subsequent cancer treatment in mouse models and cancer patients.
SELECTED KEY
PUBLICATIONS
COLLABORATIONS
Dr. Karam research involves active collaborations with national and international research institutes, including the National Center for Cancer Care & Research in Qatar and Institut Gustave Roussy in Paris, France.

Collaborator Name Institute Research Area
Salem Chouaib, PhD Institut Gustave Roussy (France) NK-based immunotherapy
Gianfranco Pittari, MD, PhD NCCCR – HMC (Qatar) NK-based immunotherapy
Alexander Knuth, MD NCCCR – HMC (Qatar) NK-based immunotherapy
Hilal A. Lashuel, PhD QBRI/EPFL (Qatar/Switzerland)
Ameena Fakhroo, PhD QBRI/Qatar University (Qatar) Anti-Cancer Activity of natural products
TEACHING
RESPONSIBILITIES
Teaching:
Institution Course Name Role
Qatar University Biochemistry (2014) Lecturer:
  • Endocrine disorders and functions (1.5h)
Qatar University Oncology (2015) Lecturer:
  • Multistep tumorigenesis and evolution of cancer (3h)
  • Cancer metastasis (3h)
  • Cancer chemotherapy (3h)
  • Targeted cancer therapies (3h)
Hamad Bin Khalifa University Advanced molecular biology (2015) Tutor:
  • Capping and poly-adenylation mechanisms and their impact on mRNA fate (3h)
Hamad Bin Khalifa University Techniques in biochemistry and molecular and cellular biology (2016) Teacher:
  • Participation in the preparation of the course program and booklet
  • Participation in the teaching of the cellular and molecular biology techniques (10 weeks)
Qatar University Oncology (2016) Lecturer:
  • Overview of the hallmarks of cancer biology and cancer signaling (2.5h)
  • Multistep tumorigenesis and evolution of cancer (2.5h)
MENTORING
Name Institution Period
Miss Aya Gaballa Carnegie Mellon University in Qatar May 10th to July 2nd 2015
Mr Ali Abouelghar Carnegie Mellon University in Qatar May 10th to July 16th 2015
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