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The Protein Biophysics and Structural Biology Core will be the only high quality comprehensive protein laboratory in Doha, which enables protein purification, multi-functional screening (protein-protein, protein-DNA interactions) and structural biology studies. The nature and complexity of protein research requires highly sophisticated technologies and advanced instrumentation. The needs of protein studies are very diverse, comprising studies of single proteins, protein complexes and interactions of groups of proteins, which may relate to structure, function or biology. This core is committed to facilitate these needs within QBRI and Qatar. The X-ray crystallography facility will house a mosquito LCP crystallization robot which can carry out both membrane and non-membrane protein crystallizations. X-ray crystallography will also be supported by the latest generation microfocus source with high intensity as well as a robust and sensitive CMOS detector. The facility will also have a cryostream with air compressor. Instrumentation will facilitate rapid screening of macromolecular crystals as well as data collection for structure determination. In addition several nitrogen dewars will be housed for storage and transport of crystals to synchrotron facilities. All crystallographic software will be maintained by support staff.
This core will provide technology from protein purification, identification and characterization up to structural investigation. In addition, reagents such as antibodies (monoclonal, polyclonal) can be developed ensuing further studies in different directions. Through access to the Advanced Microscopy Core, protein localization and trafficking can be explored.
QBRI is currently looking to recruit highly-skilled individuals for a number of roles.
Inger van Steenoven, Nour K. Majbour, Nishant Vaikath, Henk W. Berendse, Wiesje M. van der Flier, Wilma D.J. van de Berg, Charlotte E. Teunissen, Afina W. Lemstra, and Omar M.A. El-Agnaf
Journal: Movement Disorders. Article DOI: 10.1002/mds.111, Article ID: MDS111, Internal Article ID: 15859369
Caroline Spasojevic, Elisabetta Marangoni, Sophie Vacher, Franck Assayag, Didier Meseure, Sophie Château-Joubert, Martine Humbert, Manale Karam, Jean Marc Ricort, Christian Auclair, Marie Regairaz and Ivan Bièche (2018).
Oncotarget. Doi: 10.18632/oncotarget.25292
Ali Abouelghar, Reem Hasnah, Ghina Taouk, Mohamad Saad and Manale Karam (2018).
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