Publications by QBRI Scientists

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Effects of Oxidative and Thermal Stresses on Stress Granule Formation in Human Induced Pluripotent Stem Cells

Freshteh Y Pelangi, Samson M. Samuel, I. Richard Thompson, Chris R. Triggle, Mohamed M. Emara.

Plos ONE. 2017; 12(7): e0182059. doi:/10.1371/journal.pone.0182059
Abstract and details.

A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification [version 1; referees: awaiting peer review]

Jessica Roelands, Julie Decock, Sabri Boughorbel, Darawan Rinchai, Cristina Maccalli, Michele Ceccarelli, Michael Black, Chris Print, Jeff Chou, Scott Presnell, Charlie Quinn, Puthen Jithesh, Najeeb Syed, Salha B.J. Al Bader, Shahinaz Bedri, Ena Wang, Francesco M. Marincola1, Damien Chaussabel, Peter Kuppen, Lance D. Miller, Davide Bedognetti, Wouter Hendrickx.

F1000Research. 2017; 6:296. doi: 10.12688/f1000research.10960.1
Abstract and details.

PTBP1: A candidate gene for intellectual disability

Asem M. Alkhateeb, Wesal Habbab, Samah K. Aburahma, I. Richard Thompson.

Meta Gene. 2017; 13;57–62. doi: 10.1016/j.mgene.2017.05.002
Abstract and details.

Pathways governing development of stem cell-derived pancreatic β cells: lessons from embryogenesis

Al-Khawaga S, Memon B, Butler AE, Taheri S, Abou-Samra AB, Abdelalim EM.

Biol Rev Camb Philos Soc. 2017. doi: 10.1111/brv.12349
Abstract and details.

Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach

Bonnefond A, Yengo L, Dechaume A, Canouil M, Castelain M, Roger E, Allegaert F, Caiazzo R, Raverdy V, Pigeyre M, Arredouani A, Borys JM, Lévy-Marchal C, Weill J, Roussel R, Balkau B, Marre M, Pattou F, Brousseau T, Froguel P.

BMC Med. 2017 Feb 23;15(1):37. doi: 10.1186/s12916-017-0784-x
Abstract and details.

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study

Telomeres Mendelian Randomization Collaboration., Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Albagha O, et al.

JAMA Oncol. 2017;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945
Abstract and details.

Comprehensive whole genome sequence analyses yields novel genetic and structural insights for Intellectual Disability

Zahir FR, Mwenifumbo JC, Chun HE, Lim EL, Van Karnebeek CDM, Couse M, Mungall KL, Lee L, Makela N, Armstrong L, Boerkoel CF, Langlois SL, McGillivray BM, Jones SJM, Friedman JM, Marra MA.

BMC Genomics. 2017;18(1):403. doi: 10.1186/s12864-017-3671-0
Abstract and details.

Tau deletion promotes brain insulin resistance

Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy P, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L, Blum D.

J Exp Med. 2017. doi: 10.1084/jem.20161731
Abstract and details.

A chromosomal microdeletion of 15q in a female patient with epilepsy, ID, and autism spectrum disorder: a case report

Ahram DF, Al-Sarraj Y, Taha RZ, Elhag SF, Al-Shaban FA, El-Shanti H, Kambouris M.

Clin Case Rep. 2017;5(6):1013-1017. doi: 10.1002/ccr3.945
Abstract and details.

Myeloid cells in circulation and tumor microenvironment of breast cancer patients

Toor SM, Syed Khaja AS, El Salhat H, Faour I, Kanbar J, Quadri AA, Albashir M, Elkord E.

Cancer Immunol Immunother. 2017 Jun;66(6):753-764. doi: 10.1007/s00262-017-1977-z
Abstract and details.

Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment

Syed Khaja AS, Toor SM, El Salhat H, Faour I, Ul Haq N, Ali BR, Elkord E.

Oncotarget. 2017 May 16;8(20):33159-33171. doi: 10.18632/oncotarget.16565
Abstract and details.

Neuropathy of type 1 diabetes in the Arab world: A systematic review and meta-analysis

Abdel-Motal UM, Abdelalim EM, Abou-Saleh H, Zayed H.

Diabetes Res Clin Pract. 2017;127:172-180. doi: 10.1016/j.diabres.2017.03.001
Abstract and details.

Cognitive impairment in Parkinson's disease

Nour Majbour, Omar El-Agnaf.

The Lancet Neurology. 2017; 16(1),23–24. doi: 10.1016/S1474-4422(16)30329-5
Abstract and details.

Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease

Nour K. Majbour, Davide Chiasserini, Nishant N. Vaikath, Paolo Eusebi, Takahiko Tokuda, Wilma van de Berg, Lucilla Parnetti, Paolo Calabresi & Omar M. A. El-Agnaf.

Scientific Reports. 2017;7,40263 . doi: 10.1038/srep40263
Abstract and details.

Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects

Tomlinson JJ, Shutinoski B, Dong L, Meng F, Elleithy D, Lengacher NA, Nguyen AP, Cron GO, Jiang Q, Roberson ED, Nussbaum RL, Majbour NK, El-Agnaf OM, Bennett SA, Lagace DC, Woulfe JM, Sad S, Brown EG, Schlossmacher MG.

J Neural Transm (Vienna). 2017 Jun;124(6):721-738. doi: 10.1007/s00702-017-1726-7
Abstract and details.

Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy

El-Agnaf O, Overk C, Rockenstein E, Mante M, Florio J, Adame A, Vaikath N, Majbour N, Lee SJ, Kim C, Masliah E, Rissman RA.

Neurobiol Dis. 2017;104:85-96. doi: 10.1016/j.nbd.2017.05.002
Abstract and details.

Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium

McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, Ferman TJ, Ffytche D, Fujishiro H, Galasko D, Goldman JG, Gomperts SN, Graff-Radford NR, Honig LS, Iranzo A, Kantarci K, Kaufer D, Kukull W, Lee VMY, Leverenz JB, Lewis S, Lippa C, Lunde A, Masellis M, Masliah E, McLean P, Mollenhauer B, Montine TJ, Moreno E, Mori E, Murray M, O'Brien JT, Orimo S, Postuma RB, Ramaswamy S, Ross OA, Salmon DP, Singleton A, Taylor A, Thomas A, Tiraboschi P, Toledo JB, Trojanowski JQ, Tsuang D, Walker Z, Yamada M, Kosaka K.

Neurology. 2017;89(1):88-100. doi: 10.1212/WNL.0000000000004058
Abstract and details.

Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

Sarper M, Allen MD, Gomm J, Haywood L, Decock J, Thirkettle S, Ustaoglu A, Sarker SJ, Marshall J, Edwards DR, Jones JL.

Breast Cancer Research. 2017;19(1):33. doi: 10.1186/s13058-017-0822-9
Abstract and details.

An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos

Lee WJ, Chatterjee S, Yap SP, Lim SL, Xing X, Kraus P, Sun W, Hu X, Sivakamasundari V, Chan HY, Kolatkar PR, Prabhakar S, Lufkin T.

Biomed Res Int. 2017;2017:8932583. doi: 10.1155/2017/8932583
Abstract and details.

Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death

Samuel SM, Ghosh S, Majeed Y, Arunachalam G, Emara MM, Ding H, Triggle CR.

Biochem Pharmacol. 2017 May 15;132:118-132. doi: 10.1016/j.bcp.2017.03.001
Abstract and details.

Application of High-Dimensional Statistics and Network Based Visualization Techniques on Arab Diabetes and Obesity Data

Raghvendra Mall, Reda Rawi, Ehsan Ullah, Khalid Kunji, Abdelkrim Khadir, Ali Tiss, Jehad Abubaker, Michal A Kulinski, Mohammad M Ramzi, Mohammed Dehbi and Halima Bensmail.

J. Health Medical Informatics. 2017;8:2. doi: 10.4172/2157-7420.1000257
Abstract and details.

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation

Sophie Vieweg, Annalisa Ansaloni, Zhe-Ming Wang, John B. Warner and Hilal A. Lashuel.

The Journal of Biological Chemistry. 2016;291:12074-12086. doi: 10.1074/jbc.M116.713982
Abstract and details.

Nanoscale studies link amyloid maturity with polyglutamine diseases onset

F. S. Ruggeri, S. Vieweg, U. Cendrowska, G. Longo, A. Chiki, H. A. Lashuel & G. Dietler.

Scientific Reports 6:31155 . doi: 10.1038/srep31155
Abstract and details.

The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity

Roulland Y, Ouararhni K, Naidenov M, Ramos L, Shuaib M, Syed SH, Lone IN, Boopathi R, Fontaine E, Papai G, Tachiwana H, Gautier T, Skoufias D, Padmanabhan K, Bednar J, Kurumizaka H, Schultz P, Angelov D, Hamiche A, Dimitrov S.

Mol Cell. 2016 Aug 18;63(4):674-85. doi: 10.1016/j.molcel.2016.06.023
Abstract and details.

Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients

Toor SM, Syed Khaja AS, El Salhat H, Bekdache O, Kanbar J, Jaloudi M, Elkord E.

Front Immunol. 2016 Dec 8;7:560. doi: 10.3389/fimmu.2016.00560

Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function

Bricambert J, Favre D, Brajkovic S, Bonnefond A, Boutry R, Salvi R, Plaisance V, Chikri M, Chinetti-Gbaguidi G, Staels B, Giusti V, Caiazzo R, Pattou F, Waeber G, Froguel P, Abderrahmani A.

Mol Metab. 2016;5(12):1200-1207. doi: 10.1016/j.molmet.2016.09.011

Glycation in Parkinson's disease and Alzheimer's disease

Vicente Miranda H, El-Agnaf OM,Outeiro TF.

Mov Disord. 2016;31(6):782-90. doi: 10.1002/mds.26566

Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N-Methyl-D-Aspartate Receptor Subunit

Tozzi A, de Iure A, Bagetta V, Tantucci M, Durante V, Quiroga-Varela A, Costa C, Di Filippo M, Ghiglieri V, Latagliata EC, Wegrzynowicz M, Decressac M, Giampà C, Dalley JW, Xia J, Gardoni F, Mellone M, El-Agnaf OM, Ardah MT, Puglisi-Allegra S, Björklund A, Spillantini MG, Picconi B, Calabresi P.

Biol Psychiatry. 2016;79(5):402-14. doi: 10.1016/j.biopsych.2015.08.013

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease

Majbour NK, Vaikath NN, van Dijk KD, Ardah MT, Varghese S, Vesterager LB, Montezinho LP, Poole S, Safieh-Garabedian B, Tokuda T, Teunissen CE, Berendse HW, van de Berg WD, El-Agnaf OM.

Mol Neurodegener. 2016 Jan 19;11:7. doi: 10.1186/s13024-016-0072-910.1111/nmo.12985

Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice

Helwig M, Klinkenberg M, Rusconi R, Musgrove RE, Majbour NK, El-Agnaf OM, Ulusoy A, Di Monte DA.

Brain. 2016;139(Pt 3):856-70. doi: 10.1093/brain/awv376

A First Tetraplex Assay for the Simultaneous Quantification of Total α-Synuclein, Tau, β-Amyloid42 and DJ-1 in Human Cerebrospinal Fluid

Kruse N, Schlossmacher MG, Schulz-Schaeffer WJ, Vanmechelen E, Vanderstichele H, El-Agnaf OM, Mollenhauer B.

PLoS One. 2016;11(4):e0153564. doi: 10.1371/journal.pone.0153564

Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders

Javed H, Menon SA, Al-Mansoori KM, Al-Wandi A, Majbour NK, Ardah MT, Varghese S, Vaikath NN, Haque ME, Azzouz M, El-Agnaf OM.

Mol Ther. 2016;24(4):746-58. doi: 10.1038/mt.2015.232

Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function

Kim DK, Lim HS, Kawasaki I, Shim YH, Vaikath NN, El-Agnaf OM, Lee HJ, Lee SJ.

Autophagy. 2016. 12(10):1849-1863. doi: 10.1080/15548627.2016.1207014

Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression

Majbour, Nour K.; Vaikath, Nishant N.; Eusebi, Paolo; Chiasserini, Davide; Ardah, Mustafa; Varghese, Shiji; Haque, M. Emdadul; Tokuda, Takahiko; Auinger, Peggy; Calabresi, Paolo; Parnetti, Lucilla and El-Agnaf, Omar M.A.

Movement Disorders. 2016. 31(10) doi: 10.1002/mds.26754

A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.

Landeck, Natalie, Hall, Hélène, Ardah, Mustafa T., Majbour, Nour K., El-Agnaf, Omar M. A., Halliday, Glenda and Kirik, Deniz

Molecular Neurodegeneration. 2016. 11(1):61. doi: 10.1186/s13024-016-0125-0

Impact of Statistical Models on the Prediction of Type 2 Diabetes Using Non-Targeted Metabolomics Profiling

Loic Yengo, Abdelilah Arredouani, Michel Marre, Ronan Roussel, Martine Vaxillaire, Mario Falchi, Abdelali Haoudi, Jean Tichet, The D.E.S.I.R Study Group, Beverley Balkau, Amélie Bonnefond, Philippe Froguel


Metabolomic Profile of Low Copy-Number Carriers at the Salivary Alpha-Amylase Gene Suggests a Metabolic Shift Towards Lipid-Based Energy Production

Arredouani A, Stocchero M, Culeddu N, El-Sayed Moustafa J; D.E.S.I.R. study group, Tichet J, Balkau B, Brousseau T, Manca M, Falchi M

PMID: 27436124 DOI: 10.2337/db16-0315
Diabetes 2016 Jul; db160315.

Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone

Abdelkrim Khadir, Sina Kavalakatt, Jehad Abubaker, Preethi Cherian, Dhanya Madhu, Irina Al-Khairi, Mohamed Abu-Farha, Samia Warsame, Naser Elkum, Mohammed Dehbi, Ali Tiss

Metabolism Clinical and Experimental. 2016; 1409-20. doi:10.1021/j.metabol.2016.06.004

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

Dikiy I, Fauvet B, Jovičić A, Mahul-Mellier AL, Desobry C, El-Turk F, Gitler AD, Lashuel HA, Eliezer D.

ACS Chemical Biology. 2016; doi:10.1021/acschembio.6b00539

Regulation of Expression of Venom Toxins: Silencing of Prothrombin Activator Trocarin D by AG-Rich Motifs

Han SX, Kwong S, Ge R, Kolatkar PR, Woods AE, Blanchet G, Kini RM.
FASEB J. 2016 Jun;30(6):2411-25. doi: 10.1096/fj.201600213R. Epub 2016 Mar 16.
PMID: 26985007

Structure and Decoy-Mediated Inhibition of the SOX18/Prox1-DNA Interaction

Klaus M, Prokoph N, Girbig M, Wang X, Huang YH, Srivastava Y, Hou L, Narasimhan K, Kolatkar PR, Francois M, Jauch R.
Nucleic Acids Res. 2016 May 5;44(8):3922-35. doi: 10.1093/nar/gkw130. Epub 2016 Mar 2.
PMID: 26939885

Novel mutations in WWOX, RARS2, and C10orf2 genes in consanguineous Arab families with intellectual disability

Alkhateeb, Asem M., Aburahma, Samah K., Habbab, Wesal and Thompson, I. Richard

Metabolic Brain Disease. 2016; doi:10.1007/s11011-016-9827-9

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins enables New Insights into the PolyQ Dependence of Httex1 Aggregation and Fibril Formation

Sophie Vieweg, Annalisa Ansaloni, Zhe-Ming Wang, John B. Warner and Hilal A. Lashuel

Journal of Biological Chemistry. 2016; jbc.M116.713982. doi:10.1074/jbc.M116.713982

Application of Fourier Transform Infrared (FTIR) Spectroscopy and Atomic Force Microscopy in Stroke-Affected Brain Tissue

Mohamed. H. M. Ali, Khalid Al-Saad, Anton Popelka, Geralda van Tilborg, Erik Goormaghtigh.

Swift Journal of Medicine and Medical Sciences. 2016; 2(2), pp. 11-24.

The Utility of α-synuclein as Biofluid Marker in Neurodegenerative Diseases: a Systematic Review of the Literature

A.H. Simonsen, B. Kuiperij, O.M.A. El-Agnaf, S. Engelborghs, S.K. Herukka, L. Parnetti, I. Rektorova, E. Vanmechelen, E. Kapaki, M. Verbeek, B. Mollenhauer

Biomark Med. 2016 Jan;10(1):19-34

Oligomeric and Phosphorylated Alpha-Synuclein as Potential CSF Biomarkers for Parkinson's Disease

N. K. Majbour, N.N. Vaikath, K.D. van Dijk, M.T. Ardah, S. Varghese, C.E. Teunissen, L.B.Vesterager, L.P. Montezinho, S. Poole, B. Safieh-Garabedian, T. Tokuda, H.W. Berendse, W.D.J. van de Berg and O.M.A. El-Agnaf

Mol Neurodegener. 2016 Jan 19;11(1):7. doi: 10.1186/s13024-016-0072-9

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Fauvet B and Lashuel HA

Methods in Molecular Biology, 2016;1345:3-20

Induction of de Novo α-Synuclein Fibrillization in a Novel Neuronal Model for Parkinson’s Disease

Fares MB, Maco B, Oueslati A, Rockenstein E, Ninkina N, Buchman V, Masliah E, Lashuel HA

Proceedings of the National Academy of Sciences USA, 2016, Feb 2. pii: 201512876.
[Epub ahead of print]

Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease

Oueslati A, Lovisa B, Perrin J, Wagnières G, van den Bergh H, Tardy Y, Lashuel HA.

PLoS One. 2015 Oct 20;10(10):e0140880. doi: 10.1371/journal.pone.0140880. eCollection 2015.

PMID: 26484876

Gender-Specific Association of Oxidative Stress and Inflammation with Cardiovascular Risk Factors in Arab Population

Abdelkrim Khadir, Ali Tiss, Sina Kavalakatt, Kazem Behbehani, Mohammed Dehbi, and Naser Elkum

Mediators of Infection. 2015:512603.

DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression

Mohamed Abu-Farha, Preethi Cherian, Irina Al-Khairi, Ali Tiss, Abdelkrim Khadir, Sina Kavalakatt, Samia Warsame, Mohammed Dehbi, Kazem Behbehani & Jehad Abubaker.

Scientific Reports. 2015; 5,14448. doi:10.1038/srep14448

Integrative 1H-NMR-based Metabolomic Profiling to Identify Type-2 Diabetes Biomarkers: An Application to a Population of Qatar

Ullah E, Shahzad M, Rawi R, Dehbi M, Suhre K, Selim M, Mook D and Bensmail H

Metabolomics. 2015. 5:136. doi: 10.4172/2153-0769.1000136

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death.

Mahul-Mellier AL, Vercruysse F, Maco B, Ait-Bouziad N, De Roo M, Muller D, Lashuel HA.

Cell Death Differ.. 2015 Jul 3. doi: 10.1038/cdd.2015.79.

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation.

Favennec M, Hennart B, Caiazzo R, Leloire A, Yengo L, Verbanck M, Arredouani A, Marre M, Pigeyre M, Bessede A, Guillemin GJ, Chinetti G, Staels B, Pattou F, Balkau B, Allorge D, Froguel P, Poulain-Godefroy O.

Obesity. 2015. doi:10.1002/oby.21199.

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.

J Biol Chem. 2015 Aug 28;290(35):21376-92. doi: 10.1074/jbc.M115.671248.

A STIM1-dependent 'trafficking trap' mechanism regulates Orai1 plasma membrane residence and Ca2+ influx levels.

Hodeify R, Selvaraj S, Wen J, Arredouani A, Hubrack S, Dib M, Al-Thani SN, McGraw T, Machaca K.

J Cell Sci.. 2015.128(16):3143-54. doi: 10.1242/jcs.172320.

Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo.

Mbefo MK, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA.

J Biol Chem.. 2015; 290:15. doi:10.1074/jbc.M114.610774.

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.

Decock J, Hendrickx W, Thirkettle S, Gutiérrez-Fernández A, Robinson SD, Edwards DR.

Breast Cancer Res.. 2015; 17:38. doi:10.1186/s13058-015-0545-8.

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization.

Ruggeri FS1, Adamcik J, Jeong JS, Lashuel HA, Mezzenga R, Dietler G..

Angew Chem Int Ed Engl.. 2015; 54(8):2462-6. doi:10.1002/anie.201409050.

Ruggeri FS1, Adamcik J, Jeong JS, Lashuel HA, Mezzenga R, Dietler G.

Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.

Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD.

Neuron.. 2015; 85(1):76-87. doi:10.1016/j.neuron.2014.11.027.

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease.

Eleuteri S, Di Giovanni S, Rockenstein E, Mante M, Adame A, Trejo M, Wrasidlo W, Wu F, Fraering PC, Masliah E, Lashuel HA.

Neurobiol Dis.. 2015; 74:144-57. doi:10.1016/j.nbd.2014.08.017.

MAP kinase phosphatase DUSP1 is overexpressed in obese humans and modulated by physical exercise

Abdelkrim Khadir, Ali Tiss, Jehad Abubaker, Mohamed Abu-Farha, Irina Al-Khairi, Preethi Cherian, Jeena John, Sina Kavalakatt, Samia Warsame, Ashraf Al-Madhoun, Fahad Al-Ghimlas, Naser Elkum, Kazem Behbehani, Said Dermime and Mohammed Dehbi.

Am. J. Physiol. Endocrinology & Metabolism. 2015; 308: E71–E83. doi:10.1152/ajpendo.00577.2013.

Decrease in Plasma Levels of α-Synuclein is Evident in Patients with Parkinson’s Disease after Elimination of Heterophilic Antibody Interference

Ryotaro Ishii, Takahiko Tokuda, Harutsugu Tatebe, Takuma Ohmichi, Takashi Kasai, Masanori Nakagawa, Toshiki Mizuno, O.M.A. El-Agnaf

PLOS ONE, 10(4):e0123162.
doi: 10.1371/journal.pone.0123162

Generation and Characterization of Novel Conformation-Specific Monoclonal Antibodies for α-Synuclein Pathology

N.N. Vaikath, N.K. Majbour, K.E. Paleologou, M.T. Ardah, E. van Dam, W.D. J. van de Berg, S.L. Forrest, L. Parkkinen, W-P. Gai, N. Hattori, M. Takanashi, S-J. Lee, D.M.A. Mann, Y. Imai, G.M. Halliday, J-Y. Li, O.M.A. El-Agnaf

Neurobiol Dis. 79:81-99

Targeting α-Synuclein as a Therapeutic Strategy for Parkinson's Disease

N.B. Lawand, N.E. Saadé, O.M. El-Agnaf, B. Safieh-Garabedian

Expert Opin Ther Targets. 19(10):1351-60

Brain Propagation of Transduced α-Synuclein Involves Non-Fibrillar Protein Species and is Enhanced in α-Synuclein Null Mice

M. Helwig, M. Klinkenberg, R. Rusconi, R.E. Musgrove, N.K. Majbour, O.M.A. El-Agnaf, A. Ulusoy and D.A. Di Monte

Brain 2015 Dec 30. pii: awv376. [Epub ahead of print]

Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders

H. Javed, S.A. Menon, K.M. Al-Mansoori, M. Al-Wandi, N.K. Majbour, M.T. Ardah, S. Varghese, N.N. Vaikath,  M.E. Haque, M. Azzouz, O.M.A. El-Agnaf

Mol Ther. 2015 Dec 24.
doi: 10.1038/mt.2015.232. [Epub ahead of print]

Advances and Challenges in the Differentiation of Pluripotent Stem Cells into Pancreatic β Cells

Abdelalim EM, Emara MM

World Journal of Stem Cells, 2015 Jan 26; 7(1): 174-81

Early Metabolomic Profiling Scores Improves the Prediction of Type2 Diabetes in the Prospective D.E.S.I.R. Study

Loïc Yengo, Abdelilah Arredouani, Michel Marre, Beverley Balkau, Amélie Bonnefond, Philippe Froguel

Diabetes June 2015, 64:Supplement1. A1-A100; doi:10.2337/db15-1-385

TLR2, TLR4 and CD86 Gene Polymorphisms in Recurrent Aphthous Stomatitis

Karasneh J, Bani-Hani M, Alkhateeb A, Hassan A, Alzoubi F, Thornhill M

J Oral Pathol Med. 44:857-863

Arranging Marriage; Negotiating Risk: Genetics and Society in Qatar

Kilshaw S1, Al Raisi T, Alshaban F

Anthropol Med. 2015; 22(2):98-113.
doi: 10.1080/13648470.2014.976542. Epub 2015 Jan 22

DNA-Mediated Cooperativity Facilitates the Co-Selection of Cryptic Enhancer Sequences by SOX2 and PAX6 Transcription Factors

Narasimhan K, Pillay S, Huang YH, Jayabal S, Udayasuryan B, Veerapandian V, Kolatkar P, Cojocaru V, Pervushin K, Jauch R

Nucleic Acids Res. 2015 Feb 18;43(3):1513-28

Caffeine Impact on Metabolic Syndrome Components is Modulated by a CYP1A2 Variant

Platt DE, Ghassibe-Sabbagh M, Salloum AK, Mouzaya F, Gauguier D, Al-Sarraj Y, El-Shanti H, Zalloua PA, Abchee AB

Ann Nutr Metab. 2015; 21;68(1):1-11

Genetic Testing and Genomic Analysis: a Debate on Ethical, Social and Legal Issues in the Arab World with a Focus on Qatar

El Shanti H, Chouchane L, Badii R, Gallouzi IE, Gasparini P

J Transl Med. 2015 Nov 14;13(1):358 

Interleukin-1 Receptor Antagonist Deficiency with a Novel Mutation; Late Onset and Successful Treatment with Canakinumab

Ulusoy E, Karaca NE, El-Shanti H, Kilicoglu E, Aksu G, Kutukculer N

Case Report. J Med Case Rep. 2015 Jun 23;9:145

Seizures Are Regulated by Ubiquitin-specific Peptidase 9 X-linked (USP9X), a De-Ubiquitinase

Paemka L, Mahajan VB, Ehaideb SN, Skeie JM, Tan MC, Wu S, Cox AJ, Sowers LP, Gecz J, Jolly L, Ferguson PJ, Darbro B, Schneider A, Scheffer IE, Carvill GL, Mefford HC, El-Shanti H, Wood S, Manak JR, Bassuk AG

PLoS Genet.2015; 11(3):e1005022

Overlap of Familial Mediterranean Fever and Hyper-IgD Syndrome in an Arabic Kindred

Moussa T, Aladbe B, Taha R, Remmers EF, El-Shanti H, Fathalla B

Journal of Clinical Immunology. April 2015, Volume 35, Issue 3, pp 249-253

Targeting Proapoptotic Protein BAD Inhibits Survival and Self-Renewal of Cancer Stem Cells

Sastry KS, Al-Muftah MA, Li P, Al-Kowari MK, Wang E, Ismail Chouchane A, Kizhakayil D, Kulik G, Marincola FM, Haoudi A, Chouchane L

Cell Death Differ. 2014 Dec; 21(12): 1936-49.
Doi: 10.1038/cdd.2014.140. Epub 2014 Sept 12

A 12-year Survey of Methicillin-Resistant Staphylococcus Aureusinfections in Greece: ST80-IV epidemic?

E. Drougka, A. Foka, A. Liakopoulos, A. Doudoulakakis, E. Jelastopulu, V. Chini, A.Spiliopoulou, S. Levidiotou, T. Panagea, A. Vogiatzi, E. Lebessi, E. Petinaki and I.Spiliopoulou

Clin Microbiol Infect, 2014 Mar; 20:O796–O803

G-quadruplex Structures Contribute to the Neuroprotective Effects of Angiogenin-Induced tRNA Fragments

Ivanov P, O'Day E, Emara MM, Wagner G, Lieberman J, Anderson P

Proc Natl Acad Sci 2014; 111(51): 18201-18206

Association of MMP but not TIMP-1 Gene Polymorphisms with Recurrent Aphthous Stomatitis

Karasneh JA, Bani-Hani ME, Alkhateeb AM, Hassan AF, Thornhill MH

Oral Dis. 20:693–699

DNA Hypermethylation of Cell Cycle (p15 and p16) and Apoptotic (p14, p53, DAPK and TMS1) Genes in Peripheral Blood of Leukemia Patients

Bodoor K, Haddad Y, Alkhateeb A, Al-Abbadi A, Dowairi M, Magableh A, Bsoul N, Ghabkari A

Asian Pac J Cancer Prev. 15(1):75-84

Crystallization and Preliminary X-ray Diffraction Analysis of the Pax9 Paired Domain Bound to a DC5 Enhancer DNA Element

Narasimhan K, Hilbig A, Udayasuryan B, Jayabal S, Kolatkar PR, Jauch R

Acta Cryst F. Struct Biol. Commun. 2014 Oct 1;70(Pt 10):1357-61

Multivariate Epidemiologic Analysis of Type 2 Diabetes Mellitus Risks in the Lebanese Population

Ghassibe-Sabbagh M, Deeb M, Salloum AK, Mouzaya F, Haber M, Al-Sarraj Y, Chami Y, Akle Y, Hirbli K, Nemr R, Ahdab R, Platt DE, Abchee AB, El-Shanti H, Zalloua PA

Diabetology & Metabolic Syndrome. 2014; 6(1):89

T2DM GWAS in the Lebanese Population Confirms the Role of TCF7L2 and CDKAL1 in Disease Susceptibility

Ghassibe-Sabbagh M, Haber M, Salloum AK, Al-Sarraj Y, Akle Y, Hirbli K, Romanos J, Mouzaya F, Gauguier D, Platt DE, El-Shanti H, Zalloua PA

Scientific Reports 2014; 4:7351

Distal Trisomy 10q Syndrome, Report of a Patient with Duplicated q24.31 – qter, Autism Spectrum Disorder and Unusual Features

Al-Sarraj Y, Abul Al-Khair H, Taha RZ, Khattab N, El-sayed ZH, Elhusein B, El- Shanti H

Clinical Case Reports 2014;2(5):201-205

A Novel Missense Mutation in SRD5A3 Causes Congenital Disorder of Glycosylation Type I [Cerebello-Ocular Syndrome]

Al-Sarraj Y, Ben-Omran T, Tolefat M, Bejaoui Y, El-Shanti H, Kambouris M

Journal of Inborn Errors of Metabolism and Screening. 2014; 2: 2326409814550528

A Novel De Novo PSTPIP1 Mutation in a Boy with Pyogenic Arthritis, Pyoderma Gangrenosum, Acne (PAPA) Syndrome

Fathalla B, Al-Wahadneh AM, Al-Mutawa M, Kambouris M, El-Shanti H

Clin Exp Rheumatol 2014; 32(6):956-958

Structural studies on a low oxygen affinity hemoglobin from mammalian species: Sheep (Ovis aries)

Neelagandan Kamariah, Sathya Moorthy Ponnuraj, Balasubramanian Moovarkumudalvan and Mondikalipudur Nanjappa Gounder Ponnuswamy.

Biochemical and Biophysical Research Communications. 2014; 450 (1):36–41.

Micro-RNAs and Next Generation Sequencing: New perspectives in Heart Failure

Chini V.

Clinica Chimica Acta. 2014; pii: S0009-8981(14)00525-7. doi: 10.1016/j.cca.2014.11.020. PMID: 25463748

Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population

Abu-Farha M, Dehbi M, Noronha F, Tiss A, Alarouj M, Behbehani K, Bennakhi A, Elkum N.

International Journal of Endocrinology. 2014; 2014:730472. doi: 10.1155/2014/730472. Epub - 2014 Sep 9. PMID:25276131

The SOX Transcription Factors as Key Players in Pluripotent Stem Cells

Abdelalim EM1, Emara MM, Kolatkar PR.

Stem Cells Dev. 2014 Sep 26. [Epub ahead of print] PMID:25127330

Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by A disintegrin and metalloproteinase with thrombospondin motifs-15 (ADAMTS-15).

Kelwick R, Wagstaff L, Decock J, Roghi C, Cooley LS, Robinson SD, Arnold H, Gavrilović J, Jaworski DM, Yamamoto K, Nagase H, Seubert B, Krüger A, Edwards DR.

Int J Cancer. 2014 Aug 6. doi: 10.1002/ijc.29129. [Epub ahead of print] PMID:25099234

Influenza A Virus Host Shutoff Disables Antiviral Stress-Induced Translation Arrest

Denys A. Khaperskyy, Mohamed M. Emara, Benjamin P. Johnston, Paul Anderson, Todd F. Hatchette, Craig McCormick

PLoS Pathogens, July 10, 2014

New Proteomic Insights on the Role of NPR-A in Regulating Self-Renewal of Embryonic Stem Cells

Sameh Magdeldin, Tadashi Yamamoto, Ikuo Tooyama, Essam M. Abdelalim

Stem Cell Reviews and Reports . 2014; 10 (4), 561-572

Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue

Ali Tiss , Abdelkrim Khadir , Jehad Abubaker , Mohamed Abu-Farha , Irina Al-Khairi , Preethi Cherian , Jeena John , Sina Kavalakatt , Samia Warsame , Fahad Al-Ghimlas , Naser Elkum , Kazem Behbehani, Said Dermime and Mohammed Dehbi.

Lipids in Health and Disease. 2014; 13:106.

Structure of liganded T-state haemoglobin from cat (Felis silvestris catus ), a low oxygen-affinity species, in two different crystal forms

Moovarkumudalvan Balasubramanian, Ponnuraj Sathya Moorthy, Kamariah Neelagandan, Ramya Ramadoss, Prasanna R. Kolatkar and M. N. Ponnuswamy

Acta Cryst. 2014; D70:1898-1906.

Mutations in zinc finger 407 [ZNF407] cause a unique autosomal recessive cognitive impairment syndrome

Marios Kambouris, Rachid C Maroun, Tawfeg Ben-Omran, Yasser Al-Sarraj, Khaoula Errafii, Rehab Ali, Hala Boulos, Patrick A Curmi and Hatem El-Shanti

Orphanet Journal of Rare Diseases 2014; 9:80.

Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans

Baturcam E, Abubaker J, Tiss A, Abu-Farha M, Khadir A, Al-Ghimlas F, Al-Khairi I, Cherian P, Elkum N, Hammad M, John J, Kavalakatt S, Lehe C, Warsame S, Behbehani K, Dermime S & Dehbi M

Mediators Inflamm.2014:627150. doi: 10.1155/2014/627150.

IL -33 is negatively associated with the BMI and confers a protective lipid/metabolic profile in non-diabetic but not diabetic subjects.

Hasan A, Al-Ghimlas F, Warsame S, Al-Hubail A, Ahmad R, Bennakhi A, Al-Arouj M, Behbehani K, Dehbi M & Dermime S.

BMC Immunol. 2014 May 10;15(1):19.

Utilization of Gene Mapping and Candidate Gene Mutation Screening for Diagnosing Clinically Equivocal Conditions: A Norrie Disease Case Study.

Chini V, Stambouli D, Nedelea FM, Filipescu GA, Mina D, Kambouris M, El-Shanti H.

Eye Science. 2014 [In Press]

Pluripotent Stem Cells as a Potential Tool for Disease Modelling and Cell Therapy in Diabetes.

>Abdelalim EM, Bonnefond A., Annelise Bennaceur-Griscelli, Froguel P.

Stem Cell Reviews and Reports. 2014 Jun;10(3):327-37. doi: 10.1007/s12015-014-9503-6.


Knockdown of p53 suppresses Nanog expression in embryonic stem cells.

Abdelalim EM, Tooyama I.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):652-7. doi: 10.1016/j.bbrc.2013.12.030. Epub 2013 Dec 11.


Molecular Mechanisms Controlling the Cell Cycle in Embryonic Stem Cells.

Abdelalim EM.

Stem Cell Rev. 2013 Dec; 9(6):764-73. doi: 10.1007/s12015-013-9469-9


Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity.

Abu-Farha M, Tiss A, Abubaker J, Khadir A, Al-Ghimlas F, Al-Khairi I, Baturcam E, Cherian P, Elkum N, Hammad M, John J, Kavalakatt S, Warsame S, Behbehani K, Dermime S, Dehbi M.

PLoS One. 2013 Sep 24;8(9):e75342.

Exploiting human CD34+ stem cell-conditioned medium for tissue repair.

Mintz PJ, Huang KW, Reebye V, Nteliopoulos G, Lai HS, Sætrom P, Kasahara N, Jensen S, Madhava P, Gordon MY, Marley SB, Behan R, Spalding DR, Haoudi A, Emara MM, Nicholls J, Rossi JJ, Habib NA.

Molecular Therapy. 2013 Aug 28. doi: 10.1038/mt.2013.194. [Epub ahead of print]

Sox transcription factors require selective interactions with Oct4 and specific transactivation functions to mediate reprogramming.

Aksoy I, Jauch R, Eras V, Bin AC, Chen J, Divakar U, Ng CK, Kolatkar PR, Stanton LW.

Stem Cells. 2013 Aug 20. doi: 10.1002/stem.1522. [Epub ahead of print]

A novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo.

Reebye V, Saetrom P, Mintz PJ,… Emara MM, Haoudi A,… Spalding DR.

Hepatology. 2013 Aug 8. doi: 10.1002/hep.26669. [Epub ahead of print]

Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes.

Allen RE, Hughes TD, Ng JL, Ortiz RD, Ghantous MA, Bouhali O, Froguel P, Arredouani A.

Theoretical Biology and Medical Modelling. 2013 Jul 13; 10:45. doi: 10.1186/1742-4682-10-45.

What Makes a Pluripotency Reprogramming Factor?

Jauch R, Kolatkar PR.

Curr Mol Med. 2013 May 2. [Epub ahead of print]

MicroRNA-181a* Targets Nanog in a Subpopulation of CD34(+) Cells Isolated From Peripheral Blood.

Mintz PJ, Sætrom P, Reebye V, Lundbæk MB, Lao K, Rossi JJ, Gaensler KM, Kasahara N, Nicholls JP, Jensen S, Haoudi A, Emara MM, Gordon MY, Habib NA.

Mol Ther Nucleic Acids. 2012 Aug 7;1:e34. doi: 10.1038/mtna.2012.29

Hydrogen peroxide induces stress granule formation independent of eIF2a phosphorylation.

Emara MM, Fujimura K, Sciaranghella D, Ivanova V, Ivanov P, Anderson P.

Biochem Biophys Res Commun. 2012 Jul 13;423(4):763-9. doi: 10.1016/j.bbrc.2012.06.033. Epub 2012 Jun 15.

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