About QBRI


 

Publications by QBRI Scientists

2018 Publications

Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1

Memon B, Karam M, Al-Khawaga S, Abdelalim E.M. (2018) Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1. Stem Cell Research & Therapy, 2018 9:15.

Abstract and Details

Pathways governing development of stem cell‐derived pancreatic β cells: lessons from embryogenesis

Al-Khawaga S, Memon B, Butler AE, Taheri S, Abou-Samra AB, and Abdelalim EM (2018). Pathways governing development of stem cell-derived pancreatic β cells: lessons from embryogenesis. Biological Reviews, 93 (1):364-389.

Abstract and Details

Therapeutic Use of Extra-Embryonic-derived Tissues

Uhlin M*, Abumaree M*, Abdelalim EM (2018). Therapeutic Use of Extra-Embryonic-derived Tissues. Stem Cells International, in press.

Abstract and Details

Prevalence of nephropathy in type 1 diabetes in the Arab world: A systematic review and meta-analysis.

Abdel-Motal UM, G A, Abdelalim EM, Ponnuraja C C, Iken K, Jahromi M, Doss C GP, El Bekay R, Zayed H (2018).The Prevalence of Nephropathy of Type 1 Diabetes in the Arab World: A Systematic Review and Meta-analysis. Diabetes Metab Res Rev. 2018 May 17:e3026. doi: 10.1002/dmrr.3026.

Abstract and Details

Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors

Aigha II, Memon B, Elsayed AK, Abdelalim EM (2018). Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors. Stem Cell Research & Therapy, 2018 9(1):83

Abstract and Details

DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer

Sasidharan Nair V, Al Salhat H, John A, Ali BR, Elkord E. DNA methylation and repressive H3K9 and H3K27 trimethylation in the prompter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT and PD-L1 genes in human primary breast cancer. Clinical Epigenetics (in press). [IF: 4.987]

Abstract and Details

Dual inhibition of STAT1 and STAT3 activation downregulates expression of PD-L1 in human breast cancer cells

Sasidharan Nair V, Toor SM, Ali BR, Elkord E (2018). Dual inhibition of STAT1 and STAT3 activation downregulates expression of PD-L1 in human breast cancer cells. Expert Opin Ther Targets.  2018 May 2:1-11. doi: 10.1080/14728222.2018.1471137.

Abstract and Details

Therapeutic prospects of targeting myeloid‐derived suppressor cells and immune checkpoints in cancer

Toor SM, Elkord E (2018). Therapeutic prospects of targeting myeloid-derived suppressor cells and immune checkpoints in cancer. Immunol Cell Biol. 2018 Apr 10. doi: 10.1111/imcb.12054.

Abstract and Details

Immune checkpoint inhibitors in cancer therapy: a focus on T‐regulatory cells

Sasidharan Nair V, Elkord E (2018). Immune checkpoint inhibitors in cancer therapy: a focus on T-regulatory cells. Immunol Cell Biol. 2018 Jan;96(1):21-33. doi: 10.1111/imcb.1003.

Abstract and Details

In‐vitro effect of pembrolizumab on different T regulatory cell subsets

Toor SM, Syed Khaja AS, Alkurd I, Elkord E (2018). In-vitro effect of pembrolizumab on different T regulatory cell subsets. Clin Exp Immunol. 2018 Feb ;191(2) :189-197.

Abstract and Details

Physical Exercise Enhanced Heat Shock Protein 60 Expression and Attenuated Inflammation in the Adipose Tissue of Human Diabetic Obese

A. Khadir, S. Kavalakatt, P. Cherian, J. Abubaker, S. Warsame, M. Dehbi and A. Tiss (2018). Physical Exercise Enhanced Heat Shock Protein 60 Expression and Attenuated Inflammation in the Adipose Tissue of Human Diabetic Obese.. Frontiers in Endocrinology. 2018 Feb 6; 9: 16. doi: 10.3389/fendo.2018.00016.

Abstract and Details

Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density

Alonso N, Estrada K, Albagha OME et al. (2018). Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density. Ann Rheum Dis. 2018 Mar;77(3):378-385. doi: 10.1136/annrheumdis-2017-212469.

Abstract and Details

High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease

Salas I, Weerasekera A, Ahmed T; Callaerts-Vegh Z, Himmelreich U, D'Hooge R, Balschun D,  Saido TC, de Strooper B, Dotti CG (2018). High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease. Neurobiology of Dis. 2018 May;113:82-96. doi: 10.1016/j.nbd.2018.02.001

Abstract and Details

Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice

Van der Jeugd A, Parra-Damas A, Baeta-Corral R, Soto-Faguás CM, Ahmed T, LaFerla FM, Giménez-Llort L, D'Hooge R, Saura CA (2018). Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice. Sci Rep. 2018 Apr 24;8(1):6431. doi: 10.1038/s41598-018-24741-0.

Abstract and Details

Single mild traumatic brain injury results in transiently impaired spatial long-term memory and altered search strategies

Marschner L, Schreurs A, Lechat B, Mogensen J, Roebroek A, Ahmed T, Balschun D (2018). Single mild traumatic brain injury results in transiently impaired spatial long-term memory and altered search strategies. Behav Brain Res. 2018 Feb 27. pii: S0166-4328(18)30289-4. doi: 10.1016/j.bbr.2018.02.040.

Abstract and Details

NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives

Thomas R, Al-Khadairi G, Roelands J, Hendrickx W, Dermime S, Bedognetti D, Decock J (2018). NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives. Front Immunol. 2018 May 1;9:947. doi: 10.3389/fimmu.2018.00947.

Abstract and Details

T-Regulatory Cells in Health and Disease

 Elkord E, Sasidharan Nair V (2018).

Journal of Immunology Research, vol. 2018, Article ID 5025238, 2 pages, 2018. https://doi.org/10.1155/2018/5025238.

Abstract and Details

The role of inflammation in subventricular zone cancer

 

Chiara Bardella*, Abeer R. Al-Shammari*, Luana Soares*, Ian Tomlinson, O'Neill Eric & Francis G. Szele (2018). 

 Progress in Neurobiology. doi: 10.1016/j.pneurobio.2018.04.007

Abstract and Details

Schizophrenia-related dysbindin-1 gene is required for innate immune response and homeostasis in the developing subventricular zone

Abeer R. Al-Shammari, Sanjeev K. Bhardwaj, Ksenia Musaelyan, Lalit K. Srivastava and Francis G. Szele (2018). 
npj Schizophrenia

Abstract and Details

Prognostic values of the mRNA expression of natural killer receptor ligands and their association with clinicopathological features in breast cancer patients

 

Ali Abouelghar, Reem Hasnah, Ghina Taouk, Mohamad Saad and Manale Karam (2018).

Oncotarget. Doi:10.18632/oncotarget.25506

Abstract and Details

PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer

 

Caroline Spasojevic, Elisabetta Marangoni, Sophie Vacher, Franck Assayag, Didier Meseure, Sophie Château-Joubert, Martine Humbert, Manale Karam, Jean Marc Ricort, Christian Auclair, Marie Regairaz and Ivan Bièche (2018). 

Oncotarget. Doi: 10.18632/oncotarget.25292

Abstract and Details

Alpha-synuclein species as potential cerebrospinal fluid biomarkers for Dementia with Lewy bodies

      Inger van Steenoven, Nour K. Majbour, Nishant Vaikath, Henk W. Berendse, Wiesje M. van der Flier, Wilma D.J. van de Berg, Charlotte E. Teunissen, Afina W. Lemstra, and Omar M.A. El-Agnaf

Journal: Movement Disorders. Article DOI: 10.1002/mds.111, Article ID: MDS111, Internal Article ID: 15859369

 

Abstract and Details

DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer

Sasidharan Nair V, Toor SM, Taha RZ, Shaath H, Elkord E. (2018) 

Clin Epigenetics. 2018 Aug 6;10(1):104. doi: 10.1186/s13148-018-0539-3.

Abstract and Details

2017 Publications

A user's guide for α‐synuclein biomarker studies in biological fluids: Perianalytical considerations

B. Mollenhauer, R. Batrla, O.M.A. El-Agnaf, et al., (2017). A user’s guide for α-synuclein biomarker studies in biological fluids: Peri-analytical considerations. Aug;32(8):1117-1130. doi: 10.1002/mds.27090.

Abstract and Details

Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy

El-Agnaf O, Overk C, Rockenstein E, Mante M, Florio J, Adame A, Vaikath N, Majbour N, Lee SJ, Kim C, Masliah E, Rissman RA.

Neurobiol Dis. 2017;104:85-96. doi: 10.1016/j.nbd.2017.05.002

Abstract and Details

Autism spectrum disorder in Qatar: Profiles and correlates of a large clinical sample

Alshaban F, Aldosari M, El Sayed Z, Tolefat M, El Hag S, Al Shammari H, Ghazal I, Fombonne E. (2017). Autism Spectrum Disorder (ASD) in Qatar: Profiles and Correlates of a Large Clinical Sample. Autism & Developmental Language Impairments.2, pp. 1-7.

Abstract and Details

Myeloid cells in circulation and tumor microenvironment of breast cancer patients

Toor SM, Syed Khaja AS, El Salhat H, Faour I, Kanbar J, Quadri AA, Albashir M, Elkord E.

Cancer Immunol Immunother. 2017 Jun;66(6):753-764. doi: 10.1007/s00262-017-1977-z

Abstract and Details

Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment

Syed Khaja AS, Toor SM, El Salhat H, Faour I, Ul Haq N, Ali BR, Elkord E.

Oncotarget. 2017 May 16;8(20):33159-33171. doi: 10.18632/oncotarget.16565

Abstract and Details

Application of High-Dimensional Statistics and Network Based Visualization Techniques on Arab Diabetes and Obesity Data

Raghvendra Mall, Reda Rawi, Ehsan Ullah, Khalid Kunji, Abdelkrim Khadir, Ali Tiss, Jehad Abubaker, Michal A Kulinski, Mohammad M Ramzi, Mohammed Dehbi and Halima Bensmail.

J. Health Medical Informatics. 2017;8:2. doi: 10.4172/2157-7420.1000257

Abstract and Details

Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death

Samuel SM, Ghosh S, Majeed Y, Arunachalam G, Emara MM, Ding H, Triggle CR.

Biochem Pharmacol. 2017 May 15;132:118-132. doi: 10.1016/j.bcp.2017.03.001

Abstract and Details

An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos

Lee WJ, Chatterjee S, Yap SP, Lim SL, Xing X, Kraus P, Sun W, Hu X, Sivakamasundari V, Chan HY, Kolatkar PR, Prabhakar S, Lufkin T.

Biomed Res Int. 2017;2017:8932583. doi: 10.1155/2017/8932583

Abstract and Details

Encyclopedia of Autism Spectrum Disorders

Alshaban, F. (2017) ‘Qatar and Autism’, Springer Science+Business Media LLC 2018 F.R. Volkmar (ed.), Encyclopedia of Autism Spectrum Disorders, doi 10.1007/978-1-4614-6435-8_102230-1.

Abstract and Details

Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium

McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, Ferman TJ, Ffytche D, Fujishiro H, Galasko D, Goldman JG, Gomperts SN, Graff-Radford NR, Honig LS, Iranzo A, Kantarci K, Kaufer D, Kukull W, Lee VMY, Leverenz JB, Lewis S, Lippa C, Lunde A, Masellis M, Masliah E, McLean P, Mollenhauer B, Montine TJ, Moreno E, Mori E, Murray M, O'Brien JT, Orimo S, Postuma RB, Ramaswamy S, Ross OA, Salmon DP, Singleton A, Taylor A, Thomas A, Tiraboschi P, Toledo JB, Trojanowski JQ, Tsuang D, Walker Z, Yamada M, Kosaka K.

Neurology. 2017;89(1):88-100. doi: 10.1212/WNL.0000000000004058

Abstract and Details

Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects

Tomlinson JJ, Shutinoski B, Dong L, Meng F, Elleithy D, Lengacher NA, Nguyen AP, Cron GO, Jiang Q, Roberson ED, Nussbaum RL, Majbour NK, El-Agnaf OM, Bennett SA, Lagace DC, Woulfe JM, Sad S, Brown EG, Schlossmacher MG.

J Neural Transm (Vienna). 2017 Jun;124(6):721-738. doi: 10.1007/s00702-017-1726-7

Abstract and Details

Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease

Nour K. Majbour, Davide Chiasserini, Nishant N. Vaikath, Paolo Eusebi, Takahiko Tokuda, Wilma van de Berg, Lucilla Parnetti, Paolo Calabresi & Omar M. A. El-Agnaf.

Scientific Reports. 2017;7,40263 . doi: 10.1038/srep40263

Abstract and Details

Cognitive impairment in Parkinson's disease

Nour Majbour, Omar El-Agnaf.

The Lancet Neurology. 2017; 16(1),23–24. doi: 10.1016/S1474-4422(16)30329-5

Abstract and Details

Recent Advances in Stem Cells

Abdelalim EM and Emara MM. (2017). Pluripotent stem cell-derived pancreatic beta cells: from In vitro maturation to clinical applications. Recent Advances in Stem Cells: From Basic Research to Clinical Applications, ISBN 978-319-33270-3, pp 101-129, Springer.

Abstract and Details

Neuropathy of type 1 diabetes in the Arab world: A systematic review and meta-analysis

Abdel-Motal UM, Abdelalim EM, Abou-Saleh H, Zayed H.

Diabetes Res Clin Pract. 2017;127:172-180. doi: 10.1016/j.diabres.2017.03.001

Abstract and Details

A chromosomal microdeletion of 15q in a female patient with epilepsy, ID, and autism spectrum disorder: a case report

Ahram DF, Al-Sarraj Y, Taha RZ, Elhag SF, Al-Shaban FA, El-Shanti H, Kambouris M.

Clin Case Rep. 2017;5(6):1013-1017. doi: 10.1002/ccr3.945

Abstract and Details

Tau deletion promotes brain insulin resistance

Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy P, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L, Blum D.

J Exp Med. 2017. doi: 10.1084/jem.20161731

Abstract and Details

Comprehensive whole genome sequence analyses yields novel genetic and structural insights for Intellectual Disability

Zahir FR, Mwenifumbo JC, Chun HE, Lim EL, Van Karnebeek CDM, Couse M, Mungall KL, Lee L, Makela N, Armstrong L, Boerkoel CF, Langlois SL, McGillivray BM, Jones SJM, Friedman JM, Marra MA.

BMC Genomics. 2017;18(1):403. doi: 10.1186/s12864-017-3671-0

Abstract and Details

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study

Telomeres Mendelian Randomization Collaboration., Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Albagha O, et al.

JAMA Oncol. 2017;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945

Abstract and Details

Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach

Bonnefond A, Yengo L, Dechaume A, Canouil M, Castelain M, Roger E, Allegaert F, Caiazzo R, Raverdy V, Pigeyre M, Arredouani A, Borys JM, Lévy-Marchal C, Weill J, Roussel R, Balkau B, Marre M, Pattou F, Brousseau T, Froguel P.

BMC Med. 2017 Feb 23;15(1):37. doi: 10.1186/s12916-017-0784-x

Abstract and Details

Pathways governing development of stem cell-derived pancreatic β cells: lessons from embryogenesis

Al-Khawaga S, Memon B, Butler AE, Taheri S, Abou-Samra AB, Abdelalim EM.

Biol Rev Camb Philos Soc. 2017. doi: 10.1111/brv.12349

Abstract and Details

PTBP1: A candidate gene for intellectual disability

Asem M. Alkhateeb, Wesal Habbab, Samah K. Aburahma, I. Richard Thompson.

Meta Gene. 2017; 13;57–62. doi: 10.1016/j.mgene.2017.05.002

Abstract and Details

A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification [version 1; referees: awaiting peer review]

Jessica Roelands, Julie Decock, Sabri Boughorbel, Darawan Rinchai, Cristina Maccalli, Michele Ceccarelli, Michael Black, Chris Print, Jeff Chou, Scott Presnell, Charlie Quinn, Puthen Jithesh, Najeeb Syed, Salha B.J. Al Bader, Shahinaz Bedri, Ena Wang, Francesco M. Marincola1, Damien Chaussabel, Peter Kuppen, Lance D. Miller, Davide Bedognetti, Wouter Hendrickx.

F1000Research. 2017; 6:296. doi: 10.12688/f1000research.10960.1

Abstract and Details

Effects of Oxidative and Thermal Stresses on Stress Granule Formation in Human Induced Pluripotent Stem Cells

Freshteh Y Pelangi, Samson M. Samuel, I. Richard Thompson, Chris R. Triggle, Mohamed M. Emara.

Plos ONE. 2017; 12(7): e0182059. doi:/10.1371/journal.pone.0182059

Abstract and Details

Expression of CD94 by ex vivo-differentiated NK cells correlates with the in vitro and in vivo acquisition of cytotoxic features

Hasmim M, Khalife N, Zhang Y, Doldur M, Visentin G, Terry S, Giron-Michel J, Tang R, Delhommeau F, Dulphy N, Bourhis J-H, Louache F & Chouaib S. (2017). Expression of CD94 by ex vivo-differentiated NK cells correlates with the in vitro and in vivo acquisition of cytotoxic features. OncoImmunology. doi: 10.1080/2162402X.2017.1346763.

Abstract and Details

Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications

Roelands J, Kuppen PJK, Vermeulen L, Maccalli C, Decock J, Wang E, Marincola FM, Bedognetti D, Hendrickx W. (2017). Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications. Int J Mol Sci. 2017 Oct 24;18(10). pii: E2229. doi: 10.3390/ijms18102229. Review. PubMed PMID: 29064420.

Abstract and Details

In‐vitro effect of pembrolizumab on different T regulatory cell subsets

Toor SM, Khaja ASS, Alkurd I, Elkord E (2017). In vitro effect of pembrolizumab on different T regulatory cell subsets. Clinical and Experimental Immunology. Clinical and Experimental Immunology. doi:10.1111/cei.13060.

Abstract and Details

Comparison of Myeloid Cells in Circulation and in the Tumor Microenvironment of Patients with Colorectal and Breast Cancers

Toor SM, Elkord E. (2017). Comparison of Myeloid Cells in Circulation and in the Tumor Microenvironment of Patients with Colorectal and Breast Cancers. Journal of Immunology Research. doi: 10.1155/2017/7989020.

Abstract and Details

Early-onset parkinsonism in a pedigree with phosphoglycerate kinase deficiency and a heterozygous carrier: do PGK-1 mutations contribute to vulnerability to parkinsonism?

Sakaue S, Kasai T, Mizuta I, Suematsu M, Osone S, Azuma Y, Imamura T, Tokuda T, Kanno H, El-Agnaf OMA, Morimoto M, Nakagawa M, Hosoi H, Mizuno T.(2017). Early-onset parkinsonism in a pedigree with phosphoglycerate kinase deficiency and a heterozygous carrier: do PGK-1 mutations contribute to vulnerability to parkinsonism? NPJ Parkinsons Dis. 2017 Mar 31;3:13. doi: 10.1038/s41531-017-0014-4.

Abstract and Details

Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice

Karampetsou M, Ardah MT, Semitekolou M, Polissidis A, Samiotaki M, Kalomoiri M, Majbour N, Xanthou G, El-Agnaf OMA, Vekrellis K. (2017). Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice. doi:10.1038/s41598-017-15813-8.

Abstract and Details

Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density

Alonso N, Estrada K, Albagha O, Herrera L, et al. (2017). Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density.Ann Rheum Dis. Nov 23. doi: 10.1136/annrheumdis-2017-212469.

Abstract and Details

Stem Cell Biology and Regenerative Medicine

Abdelalim EM (Editor), (2017). Recent Advances in Stem Cells: From Basic Research to Clinical Applications” in the book series “Stem Cell Biology and Regenerative Medicine”, Springer, ISBN 978-319-33270-3.

Abstract and Details

Fourier Transform Infrared (FT-IR) and Laser Ablation Inductively Coupled Plasma–Mass Spectrometry (LA-ICP-MS) Imaging of Cerebral Ischemia: Combined Analysis of Rat Brain Thin Cuts Toward Improved Tissue Classification

Balbekova A, Lohninger H, van Tilborg GAF, Dijkhuizen RM, Bonta M, Limbeck A, Lendl B, Al-Saad KA, Ali M, Celikic M, Ofner J. (2017). Fourier Transform Infrared (FT-IR) and Laser Ablation Inductively Coupled Plasma–Mass Spectrometry (LA-ICP-MS) Imaging of Cerebral Ischemia: Combined Analysis of Rat Brain Thin Cuts Toward Improved Tissue Classification. Appl Spectrosc. 2018 Feb;72(2):241-250. doi: 10.1177/0003702817734618.

Abstract and Details

2016 Publications

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

Dikiy I, Fauvet B, Jovičić A, Mahul-Mellier AL, Desobry C, El-Turk F, Gitler AD, Lashuel HA, Eliezer D.

ACS Chemical Biology. 2016; doi:10.1021/acschembio.6b00539

Abstract and Details

Metabolomic Profile of Low Copy-Number Carriers at the Salivary Alpha-Amylase Gene Suggests a Metabolic Shift Towards Lipid-Based Energy Production

Arredouani A, Stocchero M, Culeddu N, El-Sayed Moustafa J; D.E.S.I.R. study group, Tichet J, Balkau B, Brousseau T, Manca M, Falchi M

PMID: 27436124 DOI: 10.2337/db16-0315
Diabetes 2016 Jul; db160315. http://dx.doi.org/10.2337/db16-0315

Abstract and Details

Impact of Statistical Models on the Prediction of Type 2 Diabetes Using Non-Targeted Metabolomics Profiling

Loic Yengo, Abdelilah Arredouani, Michel Marre, Ronan Roussel, Martine Vaxillaire, Mario Falchi, Abdelali Haoudi, Jean Tichet, The D.E.S.I.R Study Group, Beverley Balkau, Amélie Bonnefond, Philippe Froguel

DOI: http://dx.doi.org/10.1016/j.molmet.2016.08.011

Abstract and Details

Novel mutations in WWOX, RARS2, and C10orf2 genes in consanguineous Arab families with intellectual disability

Alkhateeb, Asem M., Aburahma, Samah K., Habbab, Wesal and Thompson, I. Richard

Metabolic Brain Disease. 2016; doi:10.1007/s11011-016-9827-9

Abstract and Details

Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone

Abdelkrim Khadir, Sina Kavalakatt, Jehad Abubaker, Preethi Cherian, Dhanya Madhu, Irina Al-Khairi, Mohamed Abu-Farha, Samia Warsame, Naser Elkum, Mohammed Dehbi, Ali Tiss

Metabolism Clinical and Experimental. 2016; 1409-20. doi:10.1021/j.metabol.2016.06.004

Abstract and Details

Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function

Kim DK, Lim HS, Kawasaki I, Shim YH, Vaikath NN, El-Agnaf OM, Lee HJ, Lee SJ.

Autophagy. 2016. 12(10):1849-1863. doi: 10.1080/15548627.2016.1207014

Abstract and Details

Induction of de Novo α-Synuclein Fibrillization in a Novel Neuronal Model for Parkinson’s Disease

Fares MB, Maco B, Oueslati A, Rockenstein E, Ninkina N, Buchman V, Masliah E, Lashuel HA

Proceedings of the National Academy of Sciences USA, 2016, Feb 2. pii: 201512876.
[Epub ahead of print]

Abstract and Details

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Fauvet B and Lashuel HA

Methods in Molecular Biology, 2016;1345:3-20

Abstract and Details

Application of Fourier Transform Infrared (FTIR) Spectroscopy and Atomic Force Microscopy in Stroke-Affected Brain Tissue

Mohamed. H. M. Ali, Khalid Al-Saad, Anton Popelka, Geralda van Tilborg, Erik Goormaghtigh.

Swift Journal of Medicine and Medical Sciences. 2016; 2(2), pp. 11-24.

Abstract and Details

Structure and Decoy-Mediated Inhibition of the SOX18/Prox1-DNA Interaction

Klaus M, Prokoph N, Girbig M, Wang X, Huang YH, Srivastava Y, Hou L, Narasimhan K, Kolatkar PR, Francois M, Jauch R.
Nucleic Acids Res. 2016 May 5;44(8):3922-35. doi: 10.1093/nar/gkw130. Epub 2016 Mar 2.
PMID: 26939885

Abstract and Details

Regulation of Expression of Venom Toxins: Silencing of Prothrombin Activator Trocarin D by AG-Rich Motifs

Han SX, Kwong S, Ge R, Kolatkar PR, Woods AE, Blanchet G, Kini RM.
FASEB J. 2016 Jun;30(6):2411-25. doi: 10.1096/fj.201600213R. Epub 2016 Mar 16.
PMID: 26985007

Abstract and Details

Oligomeric and Phosphorylated Alpha-Synuclein as Potential CSF Biomarkers for Parkinson's Disease

N. K. Majbour, N.N. Vaikath, K.D. van Dijk, M.T. Ardah, S. Varghese, C.E. Teunissen, L.B.Vesterager, L.P. Montezinho, S. Poole, B. Safieh-Garabedian, T. Tokuda, H.W. Berendse, W.D.J. van de Berg and O.M.A. El-Agnaf

Mol Neurodegener. 2016 Jan 19;11(1):7. doi: 10.1186/s13024-016-0072-9

Abstract and Details

A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.

Landeck, Natalie, Hall, Hélène, Ardah, Mustafa T., Majbour, Nour K., El-Agnaf, Omar M. A., Halliday, Glenda and Kirik, Deniz

Molecular Neurodegeneration. 2016. 11(1):61. doi: 10.1186/s13024-016-0125-0

Abstract and Details

Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression

Majbour, Nour K.; Vaikath, Nishant N.; Eusebi, Paolo; Chiasserini, Davide; Ardah, Mustafa; Varghese, Shiji; Haque, M. Emdadul; Tokuda, Takahiko; Auinger, Peggy; Calabresi, Paolo; Parnetti, Lucilla and El-Agnaf, Omar M.A.

Movement Disorders. 2016. 31(10) doi: 10.1002/mds.26754

Abstract and Details

Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders

Javed H, Menon SA, Al-Mansoori KM, Al-Wandi A, Majbour NK, Ardah MT, Varghese S, Vaikath NN, Haque ME, Azzouz M, El-Agnaf OM.

Mol Ther. 2016;24(4):746-58. doi: 10.1038/mt.2015.232

Abstract and Details

A First Tetraplex Assay for the Simultaneous Quantification of Total α-Synuclein, Tau, β-Amyloid42 and DJ-1 in Human Cerebrospinal Fluid

Kruse N, Schlossmacher MG, Schulz-Schaeffer WJ, Vanmechelen E, Vanderstichele H, El-Agnaf OM, Mollenhauer B.

PLoS One. 2016;11(4):e0153564. doi: 10.1371/journal.pone.0153564

Abstract and Details

Glycation in Parkinson's disease and Alzheimer's disease

Vicente Miranda H, El-Agnaf OM,Outeiro TF.

Mov Disord. 2016;31(6):782-90. doi: 10.1002/mds.26566

Abstract and Details

Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function

Bricambert J, Favre D, Brajkovic S, Bonnefond A, Boutry R, Salvi R, Plaisance V, Chikri M, Chinetti-Gbaguidi G, Staels B, Giusti V, Caiazzo R, Pattou F, Waeber G, Froguel P, Abderrahmani A.

Mol Metab. 2016;5(12):1200-1207. doi: 10.1016/j.molmet.2016.09.011

Abstract and Details

Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients

Toor SM, Syed Khaja AS, El Salhat H, Bekdache O, Kanbar J, Jaloudi M, Elkord E.

Front Immunol. 2016 Dec 8;7:560. doi: 10.3389/fimmu.2016.00560

Abstract and Details

The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity

Roulland Y, Ouararhni K, Naidenov M, Ramos L, Shuaib M, Syed SH, Lone IN, Boopathi R, Fontaine E, Papai G, Tachiwana H, Gautier T, Skoufias D, Padmanabhan K, Bednar J, Kurumizaka H, Schultz P, Angelov D, Hamiche A, Dimitrov S.

Mol Cell. 2016 Aug 18;63(4):674-85. doi: 10.1016/j.molcel.2016.06.023

Abstract and Details

Nanoscale studies link amyloid maturity with polyglutamine diseases onset

F. S. Ruggeri, S. Vieweg, U. Cendrowska, G. Longo, A. Chiki, H. A. Lashuel & G. Dietler.

Scientific Reports 6:31155 . doi: 10.1038/srep31155

Abstract and Details

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation

Sophie Vieweg, Annalisa Ansaloni, Zhe-Ming Wang, John B. Warner and Hilal A. Lashuel.

The Journal of Biological Chemistry. 2016;291:12074-12086. doi: 10.1074/jbc.M116.713982

Abstract and Details

Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

Sarper M, Allen MD, Gomm J, Haywood L, Decock J, Thirkettle S, Ustaoglu A, Sarker SJ, Marshall J, Edwards DR, Jones JL.

Breast Cancer Research. 2017;19(1):33. doi: 10.1186/s13058-017-0822-9

Abstract and Details

Sox2: Biology and Role in Development and Disease

Kolatkar PR, Moovarkumudalvan B, Abdelalim EM and Emara MM. (2016). Three dimensional Structure of SOX Protein–DNA Complexes. Sox2: Biology and Role in Development and Disease. 2016 ELSEVIER. P 15-24.

Abstract and Details

2015 Publications

MAP kinase phosphatase DUSP1 is overexpressed in obese humans and modulated by physical exercise

Abdelkrim Khadir, Ali Tiss, Jehad Abubaker, Mohamed Abu-Farha, Irina Al-Khairi, Preethi Cherian, Jeena John, Sina Kavalakatt, Samia Warsame, Ashraf Al-Madhoun, Fahad Al-Ghimlas, Naser Elkum, Kazem Behbehani, Said Dermime and Mohammed Dehbi.

Am. J. Physiol. Endocrinology & Metabolism. 2015; 308: E71–E83. doi:10.1152/ajpendo.00577.2013.

Abstract and Details

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.

Decock J, Hendrickx W, Thirkettle S, Gutiérrez-Fernández A, Robinson SD, Edwards DR.

Breast Cancer Res.. 2015; 17:38. doi:10.1186/s13058-015-0545-8.

Abstract and Details

Overlap of Familial Mediterranean Fever and Hyper-IgD Syndrome in an Arabic Kindred

Moussa T, Aladbe B, Taha R, Remmers EF, El-Shanti H, Fathalla B

Journal of Clinical Immunology. April 2015, Volume 35, Issue 3, pp 249-253

Abstract and Details

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation.

Favennec M, Hennart B, Caiazzo R, Leloire A, Yengo L, Verbanck M, Arredouani A, Marre M, Pigeyre M, Bessede A, Guillemin GJ, Chinetti G, Staels B, Pattou F, Balkau B, Allorge D, Froguel P, Poulain-Godefroy O.

Obesity. 2015. doi:10.1002/oby.21199.

Abstract and Details

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.

J Biol Chem. 2015 Aug 28;290(35):21376-92. doi: 10.1074/jbc.M115.671248.

Abstract and Details

Integrative 1H-NMR-based Metabolomic Profiling to Identify Type-2 Diabetes Biomarkers: An Application to a Population of Qatar

Ullah E, Shahzad M, Rawi R, Dehbi M, Suhre K, Selim M, Mook D and Bensmail H

Metabolomics. 2015. 5:136. doi: 10.4172/2153-0769.1000136

Abstract and Details

DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression

Mohamed Abu-Farha, Preethi Cherian, Irina Al-Khairi, Ali Tiss, Abdelkrim Khadir, Sina Kavalakatt, Samia Warsame, Mohammed Dehbi, Kazem Behbehani & Jehad Abubaker.

Scientific Reports. 2015; 5,14448. doi:10.1038/srep14448

Abstract and Details

Gender-Specific Association of Oxidative Stress and Inflammation with Cardiovascular Risk Factors in Arab Population

Abdelkrim Khadir, Ali Tiss, Sina Kavalakatt, Kazem Behbehani, Mohammed Dehbi, and Naser Elkum

Mediators of Infection. 2015:512603. http://dx.doi.org/10.1155/2015/512603

Abstract and Details

Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease

Oueslati A, Lovisa B, Perrin J, Wagnières G, van den Bergh H, Tardy Y, Lashuel HA.

PLoS One. 2015 Oct 20;10(10):e0140880. doi: 10.1371/journal.pone.0140880. eCollection 2015.

PMID: 26484876

Abstract and Details

Seizures Are Regulated by Ubiquitin-specific Peptidase 9 X-linked (USP9X), a De-Ubiquitinase

Paemka L, Mahajan VB, Ehaideb SN, Skeie JM, Tan MC, Wu S, Cox AJ, Sowers LP, Gecz J, Jolly L, Ferguson PJ, Darbro B, Schneider A, Scheffer IE, Carvill GL, Mefford HC, El-Shanti H, Wood S, Manak JR, Bassuk AG

PLoS Genet.2015; 11(3):e1005022

Abstract and Details

Interleukin-1 Receptor Antagonist Deficiency with a Novel Mutation; Late Onset and Successful Treatment with Canakinumab

Ulusoy E, Karaca NE, El-Shanti H, Kilicoglu E, Aksu G, Kutukculer N

Case Report. J Med Case Rep. 2015 Jun 23;9:145

Abstract and Details

Genetic Testing and Genomic Analysis: a Debate on Ethical, Social and Legal Issues in the Arab World with a Focus on Qatar

El Shanti H, Chouchane L, Badii R, Gallouzi IE, Gasparini P

J Transl Med. 2015 Nov 14;13(1):358 

Abstract and Details

DNA-Mediated Cooperativity Facilitates the Co-Selection of Cryptic Enhancer Sequences by SOX2 and PAX6 Transcription Factors

Narasimhan K, Pillay S, Huang YH, Jayabal S, Udayasuryan B, Veerapandian V, Kolatkar P, Cojocaru V, Pervushin K, Jauch R

Nucleic Acids Res. 2015 Feb 18;43(3):1513-28

Abstract and Details

Arranging Marriage; Negotiating Risk: Genetics and Society in Qatar

Kilshaw S1, Al Raisi T, Alshaban F

Anthropol Med. 2015; 22(2):98-113.
doi: 10.1080/13648470.2014.976542. Epub 2015 Jan 22

Abstract and Details

Caffeine Impact on Metabolic Syndrome Components is Modulated by a CYP1A2 Variant

Platt DE, Ghassibe-Sabbagh M, Salloum AK, Mouzaya F, Gauguier D, Al-Sarraj Y, El-Shanti H, Zalloua PA, Abchee AB

Ann Nutr Metab. 2015; 21;68(1):1-11

Abstract and Details

Early Metabolomic Profiling Scores Improves the Prediction of Type2 Diabetes in the Prospective D.E.S.I.R. Study

Loïc Yengo, Abdelilah Arredouani, Michel Marre, Beverley Balkau, Amélie Bonnefond, Philippe Froguel

Diabetes June 2015, 64:Supplement1. A1-A100; doi:10.2337/db15-1-385

Abstract and Details

Advances and Challenges in the Differentiation of Pluripotent Stem Cells into Pancreatic β Cells

Abdelalim EM, Emara MM

World Journal of Stem Cells, 2015 Jan 26; 7(1): 174-81

Abstract and Details

Micro-RNAs and Next Generation Sequencing: New perspectives in Heart Failure

Vasiliki P Chini (2015). Micro-RNAs and Next Generation Sequencing: New Perspectives in Heart Failure. Clin Chim Acta, Mar 30; 443:114-9.

Abstract and Details

Microtubule‐Binding R3 Fragment from Tau Self‐Assembles into Giant Multistranded Amyloid Ribbons

Adamcik J, Sánchez-Ferrer A, Ait-Bouziad N, Reynolds NP, Lashuel HA*, Mezzenga R. (2015). Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons. Angew Chem Int Ed Engl. 11;55(2):618-22.

Abstract and Details

2014 Publications

Pluripotent Stem Cells as a Potential Tool for Disease Modelling and Cell Therapy in Diabetes.

>Abdelalim EM, Bonnefond A., Annelise Bennaceur-Griscelli, Froguel P.

Stem Cell Reviews and Reports. 2014 Jun;10(3):327-37. doi: 10.1007/s12015-014-9503-6.

 

Abstract and Details

A Novel Missense Mutation in SRD5A3 Causes Congenital Disorder of Glycosylation Type I [Cerebello-Ocular Syndrome]

Al-Sarraj Y, Ben-Omran T, Tolefat M, Bejaoui Y, El-Shanti H, Kambouris M

Journal of Inborn Errors of Metabolism and Screening. 2014; 2: 2326409814550528

Abstract and Details

Mutations in zinc finger 407 [ZNF407] cause a unique autosomal recessive cognitive impairment syndrome

Marios Kambouris, Rachid C Maroun, Tawfeg Ben-Omran, Yasser Al-Sarraj, Khaoula Errafii, Rehab Ali, Hala Boulos, Patrick A Curmi and Hatem El-Shanti

Orphanet Journal of Rare Diseases 2014; 9:80.

Abstract and Details

Structure of liganded T-state haemoglobin from cat (Felis silvestris catus ), a low oxygen-affinity species, in two different crystal forms

Moovarkumudalvan Balasubramanian, Ponnuraj Sathya Moorthy, Kamariah Neelagandan, Ramya Ramadoss, Prasanna R. Kolatkar and M. N. Ponnuswamy

Acta Cryst. 2014; D70:1898-1906.

Abstract and Details

Utilization of Gene Mapping and Candidate Gene Mutation Screening for Diagnosing Clinically Equivocal Conditions: A Norrie Disease Case Study.

Chini V, Stambouli D, Nedelea FM, Filipescu GA, Mina D, Kambouris M, El-Shanti H.

Eye Science. 2014 [In Press]

Abstract and Details

Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans

Baturcam E, Abubaker J, Tiss A, Abu-Farha M, Khadir A, Al-Ghimlas F, Al-Khairi I, Cherian P, Elkum N, Hammad M, John J, Kavalakatt S, Lehe C, Warsame S, Behbehani K, Dermime S & Dehbi M

Mediators Inflamm.2014:627150. doi: 10.1155/2014/627150.

Abstract and Details

Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue

Ali Tiss , Abdelkrim Khadir , Jehad Abubaker , Mohamed Abu-Farha , Irina Al-Khairi , Preethi Cherian , Jeena John , Sina Kavalakatt , Samia Warsame , Fahad Al-Ghimlas , Naser Elkum , Kazem Behbehani, Said Dermime and Mohammed Dehbi.

Lipids in Health and Disease. 2014; 13:106.

Abstract and Details

Crystallization and Preliminary X-ray Diffraction Analysis of the Pax9 Paired Domain Bound to a DC5 Enhancer DNA Element

Narasimhan K, Hilbig A, Udayasuryan B, Jayabal S, Kolatkar PR, Jauch R

Acta Cryst F. Struct Biol. Commun. 2014 Oct 1;70(Pt 10):1357-61

Abstract and Details

New Proteomic Insights on the Role of NPR-A in Regulating Self-Renewal of Embryonic Stem Cells

Sameh Magdeldin, Tadashi Yamamoto, Ikuo Tooyama, Essam M. Abdelalim


Stem Cell Reviews and Reports . 2014; 10 (4), 561-572

Abstract and Details

Influenza A Virus Host Shutoff Disables Antiviral Stress-Induced Translation Arrest

Denys A. Khaperskyy, Mohamed M. Emara, Benjamin P. Johnston, Paul Anderson, Todd F. Hatchette, Craig McCormick

PLoS Pathogens, July 10, 2014

Abstract and Details

The SOX Transcription Factors as Key Players in Pluripotent Stem Cells

Abdelalim EM1, Emara MM, Kolatkar PR.

Stem Cells Dev. 2014 Sep 26. [Epub ahead of print] PMID:25127330

Abstract and Details

Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by A disintegrin and metalloproteinase with thrombospondin motifs-15 (ADAMTS-15).

Kelwick R, Wagstaff L, Decock J, Roghi C, Cooley LS, Robinson SD, Arnold H, Gavrilović J, Jaworski DM, Yamamoto K, Nagase H, Seubert B, Krüger A, Edwards DR.

Int J Cancer. 2014 Aug 6. doi: 10.1002/ijc.29129. [Epub ahead of print] PMID:25099234

Abstract and Details

Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population

Abu-Farha M, Dehbi M, Noronha F, Tiss A, Alarouj M, Behbehani K, Bennakhi A, Elkum N.

International Journal of Endocrinology. 2014; 2014:730472. doi: 10.1155/2014/730472. Epub - 2014 Sep 9. PMID:25276131

Abstract and Details

Structural studies on a low oxygen affinity hemoglobin from mammalian species: Sheep (Ovis aries)

Neelagandan Kamariah, Sathya Moorthy Ponnuraj, Balasubramanian Moovarkumudalvan and Mondikalipudur Nanjappa Gounder Ponnuswamy.

Biochemical and Biophysical Research Communications. 2014; 450 (1):36–41.

Abstract and Details

G-quadruplex Structures Contribute to the Neuroprotective Effects of Angiogenin-Induced tRNA Fragments

Ivanov P, O'Day E, Emara MM, Wagner G, Lieberman J, Anderson P

Proc Natl Acad Sci 2014; 111(51): 18201-18206

Abstract and Details

A 12-year Survey of Methicillin-Resistant Staphylococcus Aureusinfections in Greece: ST80-IV epidemic?

E. Drougka, A. Foka, A. Liakopoulos, A. Doudoulakakis, E. Jelastopulu, V. Chini, A.Spiliopoulou, S. Levidiotou, T. Panagea, A. Vogiatzi, E. Lebessi, E. Petinaki and I.Spiliopoulou

Clin Microbiol Infect, 2014 Mar; 20:O796–O803

Abstract and Details

Targeting Proapoptotic Protein BAD Inhibits Survival and Self-Renewal of Cancer Stem Cells

Sastry KS, Al-Muftah MA, Li P, Al-Kowari MK, Wang E, Ismail Chouchane A, Kizhakayil D, Kulik G, Marincola FM, Haoudi A, Chouchane L

Cell Death Differ. 2014 Dec; 21(12): 1936-49.
Doi: 10.1038/cdd.2014.140. Epub 2014 Sept 12

Abstract and Details

TLR2, TLR4 and CD86 Gene Polymorphisms in Recurrent Aphthous Stomatitis

Karasneh J, Bani-Hani M, Alkhateeb A, Hassan A, Alzoubi F, Thornhill M

J Oral Pathol Med. 44:857-863

Abstract and Details

2013 Publications

Knockdown of p53 suppresses Nanog expression in embryonic stem cells.

Abdelalim EM, Tooyama I.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):652-7. doi: 10.1016/j.bbrc.2013.12.030. Epub 2013 Dec 11.

 

Abstract and Details

What Makes a Pluripotency Reprogramming Factor?

Jauch R, Kolatkar PR.

Curr Mol Med. 2013 May 2. [Epub ahead of print]

Abstract and Details

Sox transcription factors require selective interactions with Oct4 and specific transactivation functions to mediate reprogramming.

Aksoy I, Jauch R, Eras V, Bin AC, Chen J, Divakar U, Ng CK, Kolatkar PR, Stanton LW.

Stem Cells. 2013 Aug 20. doi: 10.1002/stem.1522. [Epub ahead of print]

Abstract and Details

Exploiting human CD34+ stem cell-conditioned medium for tissue repair.

Mintz PJ, Huang KW, Reebye V, Nteliopoulos G, Lai HS, Sætrom P, Kasahara N, Jensen S, Madhava P, Gordon MY, Marley SB, Behan R, Spalding DR, Haoudi A, Emara MM, Nicholls J, Rossi JJ, Habib NA.

Molecular Therapy. 2013 Aug 28. doi: 10.1038/mt.2013.194. [Epub ahead of print]

Abstract and Details

A novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo.

Reebye V, Saetrom P, Mintz PJ,… Emara MM, Haoudi A,… Spalding DR.

Hepatology. 2013 Aug 8. doi: 10.1002/hep.26669. [Epub ahead of print]

Abstract and Details

Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes.

Allen RE, Hughes TD, Ng JL, Ortiz RD, Ghantous MA, Bouhali O, Froguel P, Arredouani A.

Theoretical Biology and Medical Modelling. 2013 Jul 13; 10:45. doi: 10.1186/1742-4682-10-45.

Abstract and Details

Molecular Mechanisms Controlling the Cell Cycle in Embryonic Stem Cells.

Abdelalim EM.

Stem Cell Rev. 2013 Dec; 9(6):764-73. doi: 10.1007/s12015-013-9469-9

 

Abstract and Details

Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity.

Abu-Farha M, Tiss A, Abubaker J, Khadir A, Al-Ghimlas F, Al-Khairi I, Baturcam E, Cherian P, Elkum N, Hammad M, John J, Kavalakatt S, Warsame S, Behbehani K, Dermime S, Dehbi M.

PLoS One. 2013 Sep 24;8(9):e75342.

Abstract and Details

Association of MMP but not TIMP-1 Gene Polymorphisms with Recurrent Aphthous Stomatitis

Karasneh JA, Bani-Hani ME, Alkhateeb AM, Hassan AF, Thornhill MH

Oral Dis. 20:693–699

Abstract and Details

2012 Publications

MicroRNA-181a* Targets Nanog in a Subpopulation of CD34(+) Cells Isolated From Peripheral Blood.

Mintz PJ, Sætrom P, Reebye V, Lundbæk MB, Lao K, Rossi JJ, Gaensler KM, Kasahara N, Nicholls JP, Jensen S, Haoudi A, Emara MM, Gordon MY, Habib NA.

Mol Ther Nucleic Acids. 2012 Aug 7;1:e34. doi: 10.1038/mtna.2012.29

Abstract and Details

Hydrogen peroxide induces stress granule formation independent of eIF2a phosphorylation.

Emara MM, Fujimura K, Sciaranghella D, Ivanova V, Ivanov P, Anderson P.

Biochem Biophys Res Commun. 2012 Jul 13;423(4):763-9. doi: 10.1016/j.bbrc.2012.06.033. Epub 2012 Jun 15.

Abstract and Details

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