Publications by QBRI Scientists

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Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression

Majbour, Nour K.; Vaikath, Nishant N.; Eusebi, Paolo; Chiasserini, Davide; Ardah, Mustafa; Varghese, Shiji; Haque, M. Emdadul; Tokuda, Takahiko; Auinger, Peggy; Calabresi, Paolo; Parnetti, Lucilla and El-Agnaf, Omar M.A.

Movement Disorders. 2016. 31(10) doi: 10.1002/mds.26754
Abstract and details.

A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.

Landeck, Natalie, Hall, Hélène, Ardah, Mustafa T., Majbour, Nour K., El-Agnaf, Omar M. A., Halliday, Glenda and Kirik, Deniz

Molecular Neurodegeneration. 2016. 11(1):61. doi: 10.1186/s13024-016-0125-0
Abstract and details.

Impact of Statistical Models on the Prediction of Type 2 Diabetes Using Non-Targeted Metabolomics Profiling

Loic Yengo, Abdelilah Arredouani, Michel Marre, Ronan Roussel, Martine Vaxillaire, Mario Falchi, Abdelali Haoudi, Jean Tichet, The D.E.S.I.R Study Group, Beverley Balkau, Amélie Bonnefond, Philippe Froguel

Abstract and details.

Metabolomic Profile of Low Copy-Number Carriers at the Salivary Alpha-Amylase Gene Suggests a Metabolic Shift Towards Lipid-Based Energy Production

Arredouani A, Stocchero M, Culeddu N, El-Sayed Moustafa J; D.E.S.I.R. study group, Tichet J, Balkau B, Brousseau T, Manca M, Falchi M

PMID: 27436124 DOI: 10.2337/db16-0315
Diabetes 2016 Jul; db160315.
Abstract and details.

Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone

Abdelkrim Khadir, Sina Kavalakatt, Jehad Abubaker, Preethi Cherian, Dhanya Madhu, Irina Al-Khairi, Mohamed Abu-Farha, Samia Warsame, Naser Elkum, Mohammed Dehbi, Ali Tiss

Metabolism Clinical and Experimental. 2016; 1409-20. doi:10.1021/j.metabol.2016.06.004

Abstract and details.

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

Dikiy I, Fauvet B, Jovičić A, Mahul-Mellier AL, Desobry C, El-Turk F, Gitler AD, Lashuel HA, Eliezer D.

ACS Chemical Biology. 2016; doi:10.1021/acschembio.6b00539

Abstract and details.

Regulation of Expression of Venom Toxins: Silencing of Prothrombin Activator Trocarin D by AG-Rich Motifs

Han SX, Kwong S, Ge R, Kolatkar PR, Woods AE, Blanchet G, Kini RM.
FASEB J. 2016 Jun;30(6):2411-25. doi: 10.1096/fj.201600213R. Epub 2016 Mar 16.
PMID: 26985007
Abstract and details.

Structure and Decoy-Mediated Inhibition of the SOX18/Prox1-DNA Interaction

Klaus M, Prokoph N, Girbig M, Wang X, Huang YH, Srivastava Y, Hou L, Narasimhan K, Kolatkar PR, Francois M, Jauch R.
Nucleic Acids Res. 2016 May 5;44(8):3922-35. doi: 10.1093/nar/gkw130. Epub 2016 Mar 2.
PMID: 26939885
Abstract and details.

Novel mutations in WWOX, RARS2, and C10orf2 genes in consanguineous Arab families with intellectual disability

Alkhateeb, Asem M., Aburahma, Samah K., Habbab, Wesal and Thompson, I. Richard

Metabolic Brain Disease. 2016; doi:10.1007/s11011-016-9827-9

Abstract and details.

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins enables New Insights into the PolyQ Dependence of Httex1 Aggregation and Fibril Formation

Sophie Vieweg, Annalisa Ansaloni, Zhe-Ming Wang, John B. Warner and Hilal A. Lashuel

Journal of Biological Chemistry. 2016; jbc.M116.713982. doi:10.1074/jbc.M116.713982

Abstract and details.

Application of Fourier Transform Infrared (FTIR) Spectroscopy and Atomic Force Microscopy in Stroke-Affected Brain Tissue

Mohamed. H. M. Ali, Khalid Al-Saad, Anton Popelka, Geralda van Tilborg, Erik Goormaghtigh.

Swift Journal of Medicine and Medical Sciences. 2016; 2(2), pp. 11-24.

Abstract and details.

The Utility of α-synuclein as Biofluid Marker in Neurodegenerative Diseases: a Systematic Review of the Literature

A.H. Simonsen, B. Kuiperij, O.M.A. El-Agnaf, S. Engelborghs, S.K. Herukka, L. Parnetti, I. Rektorova, E. Vanmechelen, E. Kapaki, M. Verbeek, B. Mollenhauer

Biomark Med. 2016 Jan;10(1):19-34
Abstract and details.

Oligomeric and Phosphorylated Alpha-Synuclein as Potential CSF Biomarkers for Parkinson's Disease

N. K. Majbour, N.N. Vaikath, K.D. van Dijk, M.T. Ardah, S. Varghese, C.E. Teunissen, L.B.Vesterager, L.P. Montezinho, S. Poole, B. Safieh-Garabedian, T. Tokuda, H.W. Berendse, W.D.J. van de Berg and O.M.A. El-Agnaf

Mol Neurodegener. 2016 Jan 19;11(1):7. doi: 10.1186/s13024-016-0072-9
Abstract and details.

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Fauvet B and Lashuel HA

Methods in Molecular Biology, 2016;1345:3-20
Abstract and details.

Induction of de Novo α-Synuclein Fibrillization in a Novel Neuronal Model for Parkinson’s Disease

Fares MB, Maco B, Oueslati A, Rockenstein E, Ninkina N, Buchman V, Masliah E, Lashuel HA

Proceedings of the National Academy of Sciences USA, 2016, Feb 2. pii: 201512876.
[Epub ahead of print]
Abstract and details.

Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease

Oueslati A, Lovisa B, Perrin J, Wagnières G, van den Bergh H, Tardy Y, Lashuel HA.

PLoS One. 2015 Oct 20;10(10):e0140880. doi: 10.1371/journal.pone.0140880. eCollection 2015.

PMID: 26484876
Abstract and details.

Gender-Specific Association of Oxidative Stress and Inflammation with Cardiovascular Risk Factors in Arab Population

Abdelkrim Khadir, Ali Tiss, Sina Kavalakatt, Kazem Behbehani, Mohammed Dehbi, and Naser Elkum

Mediators of Infection. 2015:512603.

Abstract and details.

DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression

Mohamed Abu-Farha, Preethi Cherian, Irina Al-Khairi, Ali Tiss, Abdelkrim Khadir, Sina Kavalakatt, Samia Warsame, Mohammed Dehbi, Kazem Behbehani & Jehad Abubaker.

Scientific Reports. 2015; 5,14448. doi:10.1038/srep14448

Abstract and details.

Integrative 1H-NMR-based Metabolomic Profiling to Identify Type-2 Diabetes Biomarkers: An Application to a Population of Qatar

Ullah E, Shahzad M, Rawi R, Dehbi M, Suhre K, Selim M, Mook D and Bensmail H

Metabolomics. 2015. 5:136. doi: 10.4172/2153-0769.1000136

Abstract and details.

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death.

Mahul-Mellier AL, Vercruysse F, Maco B, Ait-Bouziad N, De Roo M, Muller D, Lashuel HA.

Cell Death Differ.. 2015 Jul 3. doi: 10.1038/cdd.2015.79.

Abstract and details.

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation.

Favennec M, Hennart B, Caiazzo R, Leloire A, Yengo L, Verbanck M, Arredouani A, Marre M, Pigeyre M, Bessede A, Guillemin GJ, Chinetti G, Staels B, Pattou F, Balkau B, Allorge D, Froguel P, Poulain-Godefroy O.

Obesity. 2015. doi:10.1002/oby.21199.

Abstract and details.

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.

J Biol Chem. 2015 Aug 28;290(35):21376-92. doi: 10.1074/jbc.M115.671248.

Abstract and details.

A STIM1-dependent 'trafficking trap' mechanism regulates Orai1 plasma membrane residence and Ca2+ influx levels.

Hodeify R, Selvaraj S, Wen J, Arredouani A, Hubrack S, Dib M, Al-Thani SN, McGraw T, Machaca K.

J Cell Sci.. 2015.128(16):3143-54. doi: 10.1242/jcs.172320.

Abstract and details.

Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo.

Mbefo MK, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA.

J Biol Chem.. 2015; 290:15. doi:10.1074/jbc.M114.610774.

Abstract and details.

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.

Decock J, Hendrickx W, Thirkettle S, Gutiérrez-Fernández A, Robinson SD, Edwards DR.

Breast Cancer Res.. 2015; 17:38. doi:10.1186/s13058-015-0545-8.

Abstract and details.

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization.

Ruggeri FS1, Adamcik J, Jeong JS, Lashuel HA, Mezzenga R, Dietler G..

Angew Chem Int Ed Engl.. 2015; 54(8):2462-6. doi:10.1002/anie.201409050.

Ruggeri FS1, Adamcik J, Jeong JS, Lashuel HA, Mezzenga R, Dietler G.
Abstract and details.

Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.

Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD.

Neuron.. 2015; 85(1):76-87. doi:10.1016/j.neuron.2014.11.027.

Abstract and details.

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease.

Eleuteri S, Di Giovanni S, Rockenstein E, Mante M, Adame A, Trejo M, Wrasidlo W, Wu F, Fraering PC, Masliah E, Lashuel HA.

Neurobiol Dis.. 2015; 74:144-57. doi:10.1016/j.nbd.2014.08.017.

Abstract and details.

MAP kinase phosphatase DUSP1 is overexpressed in obese humans and modulated by physical exercise

Abdelkrim Khadir, Ali Tiss, Jehad Abubaker, Mohamed Abu-Farha, Irina Al-Khairi, Preethi Cherian, Jeena John, Sina Kavalakatt, Samia Warsame, Ashraf Al-Madhoun, Fahad Al-Ghimlas, Naser Elkum, Kazem Behbehani, Said Dermime and Mohammed Dehbi.

Am. J. Physiol. Endocrinology & Metabolism. 2015; 308: E71–E83. doi:10.1152/ajpendo.00577.2013.

Abstract and details.

Decrease in Plasma Levels of α-Synuclein is Evident in Patients with Parkinson’s Disease after Elimination of Heterophilic Antibody Interference

Ryotaro Ishii, Takahiko Tokuda, Harutsugu Tatebe, Takuma Ohmichi, Takashi Kasai, Masanori Nakagawa, Toshiki Mizuno, O.M.A. El-Agnaf

PLOS ONE, 10(4):e0123162.
doi: 10.1371/journal.pone.0123162
Abstract and details.

Generation and Characterization of Novel Conformation-Specific Monoclonal Antibodies for α-Synuclein Pathology

N.N. Vaikath, N.K. Majbour, K.E. Paleologou, M.T. Ardah, E. van Dam, W.D. J. van de Berg, S.L. Forrest, L. Parkkinen, W-P. Gai, N. Hattori, M. Takanashi, S-J. Lee, D.M.A. Mann, Y. Imai, G.M. Halliday, J-Y. Li, O.M.A. El-Agnaf

Neurobiol Dis. 79:81-99
Abstract and details.

Targeting α-Synuclein as a Therapeutic Strategy for Parkinson's Disease

N.B. Lawand, N.E. Saadé, O.M. El-Agnaf, B. Safieh-Garabedian

Expert Opin Ther Targets. 19(10):1351-60
Abstract and details.

Brain Propagation of Transduced α-Synuclein Involves Non-Fibrillar Protein Species and is Enhanced in α-Synuclein Null Mice

M. Helwig, M. Klinkenberg, R. Rusconi, R.E. Musgrove, N.K. Majbour, O.M.A. El-Agnaf, A. Ulusoy and D.A. Di Monte

Brain 2015 Dec 30. pii: awv376. [Epub ahead of print]
Abstract and details.

Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders

H. Javed, S.A. Menon, K.M. Al-Mansoori, M. Al-Wandi, N.K. Majbour, M.T. Ardah, S. Varghese, N.N. Vaikath,  M.E. Haque, M. Azzouz, O.M.A. El-Agnaf

Mol Ther. 2015 Dec 24.
doi: 10.1038/mt.2015.232. [Epub ahead of print]

Abstract and details.

Advances and Challenges in the Differentiation of Pluripotent Stem Cells into Pancreatic β Cells

Abdelalim EM, Emara MM

World Journal of Stem Cells, 2015 Jan 26; 7(1): 174-81
Abstract and details.

Early Metabolomic Profiling Scores Improves the Prediction of Type2 Diabetes in the Prospective D.E.S.I.R. Study

Loïc Yengo, Abdelilah Arredouani, Michel Marre, Beverley Balkau, Amélie Bonnefond, Philippe Froguel

Diabetes June 2015, 64:Supplement1. A1-A100; doi:10.2337/db15-1-385
Abstract and details.

TLR2, TLR4 and CD86 Gene Polymorphisms in Recurrent Aphthous Stomatitis

Karasneh J, Bani-Hani M, Alkhateeb A, Hassan A, Alzoubi F, Thornhill M

J Oral Pathol Med. 44:857-863
Abstract and details.

Arranging Marriage; Negotiating Risk: Genetics and Society in Qatar

Kilshaw S1, Al Raisi T, Alshaban F

Anthropol Med. 2015; 22(2):98-113.
doi: 10.1080/13648470.2014.976542. Epub 2015 Jan 22
Abstract and details.

DNA-Mediated Cooperativity Facilitates the Co-Selection of Cryptic Enhancer Sequences by SOX2 and PAX6 Transcription Factors

Narasimhan K, Pillay S, Huang YH, Jayabal S, Udayasuryan B, Veerapandian V, Kolatkar P, Cojocaru V, Pervushin K, Jauch R

Nucleic Acids Res. 2015 Feb 18;43(3):1513-28
Abstract and details.

Caffeine Impact on Metabolic Syndrome Components is Modulated by a CYP1A2 Variant

Platt DE, Ghassibe-Sabbagh M, Salloum AK, Mouzaya F, Gauguier D, Al-Sarraj Y, El-Shanti H, Zalloua PA, Abchee AB

Ann Nutr Metab. 2015; 21;68(1):1-11
Abstract and details.

Genetic Testing and Genomic Analysis: a Debate on Ethical, Social and Legal Issues in the Arab World with a Focus on Qatar

El Shanti H, Chouchane L, Badii R, Gallouzi IE, Gasparini P

J Transl Med. 2015 Nov 14;13(1):358 
Abstract and details.

Interleukin-1 Receptor Antagonist Deficiency with a Novel Mutation; Late Onset and Successful Treatment with Canakinumab

Ulusoy E, Karaca NE, El-Shanti H, Kilicoglu E, Aksu G, Kutukculer N

Case Report. J Med Case Rep. 2015 Jun 23;9:145
Abstract and details.

Seizures Are Regulated by Ubiquitin-specific Peptidase 9 X-linked (USP9X), a De-Ubiquitinase

Paemka L, Mahajan VB, Ehaideb SN, Skeie JM, Tan MC, Wu S, Cox AJ, Sowers LP, Gecz J, Jolly L, Ferguson PJ, Darbro B, Schneider A, Scheffer IE, Carvill GL, Mefford HC, El-Shanti H, Wood S, Manak JR, Bassuk AG

PLoS Genet.2015; 11(3):e1005022
Abstract and details.

Overlap of Familial Mediterranean Fever and Hyper-IgD Syndrome in an Arabic Kindred

Moussa T, Aladbe B, Taha R, Remmers EF, El-Shanti H, Fathalla B

Journal of Clinical Immunology. April 2015, Volume 35, Issue 3, pp 249-253

Abstract and details.

Targeting Proapoptotic Protein BAD Inhibits Survival and Self-Renewal of Cancer Stem Cells

Sastry KS, Al-Muftah MA, Li P, Al-Kowari MK, Wang E, Ismail Chouchane A, Kizhakayil D, Kulik G, Marincola FM, Haoudi A, Chouchane L

Cell Death Differ. 2014 Dec; 21(12): 1936-49.
Doi: 10.1038/cdd.2014.140. Epub 2014 Sept 12
Abstract and details.

A 12-year Survey of Methicillin-Resistant Staphylococcus Aureusinfections in Greece: ST80-IV epidemic?

E. Drougka, A. Foka, A. Liakopoulos, A. Doudoulakakis, E. Jelastopulu, V. Chini, A.Spiliopoulou, S. Levidiotou, T. Panagea, A. Vogiatzi, E. Lebessi, E. Petinaki and I.Spiliopoulou

Clin Microbiol Infect, 2014 Mar; 20:O796–O803
Abstract and details.

G-quadruplex Structures Contribute to the Neuroprotective Effects of Angiogenin-Induced tRNA Fragments

Ivanov P, O'Day E, Emara MM, Wagner G, Lieberman J, Anderson P

Proc Natl Acad Sci 2014; 111(51): 18201-18206
Abstract and details.

Association of MMP but not TIMP-1 Gene Polymorphisms with Recurrent Aphthous Stomatitis

Karasneh JA, Bani-Hani ME, Alkhateeb AM, Hassan AF, Thornhill MH

Oral Dis. 20:693–699
Abstract and details.

DNA Hypermethylation of Cell Cycle (p15 and p16) and Apoptotic (p14, p53, DAPK and TMS1) Genes in Peripheral Blood of Leukemia Patients

Bodoor K, Haddad Y, Alkhateeb A, Al-Abbadi A, Dowairi M, Magableh A, Bsoul N, Ghabkari A

Asian Pac J Cancer Prev. 15(1):75-84
Abstract and details.

Crystallization and Preliminary X-ray Diffraction Analysis of the Pax9 Paired Domain Bound to a DC5 Enhancer DNA Element

Narasimhan K, Hilbig A, Udayasuryan B, Jayabal S, Kolatkar PR, Jauch R

Acta Cryst F. Struct Biol. Commun. 2014 Oct 1;70(Pt 10):1357-61
Abstract and details.

Multivariate Epidemiologic Analysis of Type 2 Diabetes Mellitus Risks in the Lebanese Population

Ghassibe-Sabbagh M, Deeb M, Salloum AK, Mouzaya F, Haber M, Al-Sarraj Y, Chami Y, Akle Y, Hirbli K, Nemr R, Ahdab R, Platt DE, Abchee AB, El-Shanti H, Zalloua PA

Diabetology & Metabolic Syndrome. 2014; 6(1):89
Abstract and details.

T2DM GWAS in the Lebanese Population Confirms the Role of TCF7L2 and CDKAL1 in Disease Susceptibility

Ghassibe-Sabbagh M, Haber M, Salloum AK, Al-Sarraj Y, Akle Y, Hirbli K, Romanos J, Mouzaya F, Gauguier D, Platt DE, El-Shanti H, Zalloua PA

Scientific Reports 2014; 4:7351
Abstract and details.

Distal Trisomy 10q Syndrome, Report of a Patient with Duplicated q24.31 – qter, Autism Spectrum Disorder and Unusual Features

Al-Sarraj Y, Abul Al-Khair H, Taha RZ, Khattab N, El-sayed ZH, Elhusein B, El- Shanti H

Clinical Case Reports 2014;2(5):201-205
Abstract and details.

A Novel Missense Mutation in SRD5A3 Causes Congenital Disorder of Glycosylation Type I [Cerebello-Ocular Syndrome]

Al-Sarraj Y, Ben-Omran T, Tolefat M, Bejaoui Y, El-Shanti H, Kambouris M

Journal of Inborn Errors of Metabolism and Screening. 2014; 2: 2326409814550528

Abstract and details.

A Novel De Novo PSTPIP1 Mutation in a Boy with Pyogenic Arthritis, Pyoderma Gangrenosum, Acne (PAPA) Syndrome

Fathalla B, Al-Wahadneh AM, Al-Mutawa M, Kambouris M, El-Shanti H

Clin Exp Rheumatol 2014; 32(6):956-958
Abstract and details.

Structural studies on a low oxygen affinity hemoglobin from mammalian species: Sheep (Ovis aries)

Neelagandan Kamariah, Sathya Moorthy Ponnuraj, Balasubramanian Moovarkumudalvan and Mondikalipudur Nanjappa Gounder Ponnuswamy.

Biochemical and Biophysical Research Communications. 2014; 450 (1):36–41.

Abstract and details.

Micro-RNAs and Next Generation Sequencing: New perspectives in Heart Failure

Chini V.

Clinica Chimica Acta. 2014; pii: S0009-8981(14)00525-7. doi: 10.1016/j.cca.2014.11.020. PMID: 25463748

Abstract and details.

Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population

Abu-Farha M, Dehbi M, Noronha F, Tiss A, Alarouj M, Behbehani K, Bennakhi A, Elkum N.

International Journal of Endocrinology. 2014; 2014:730472. doi: 10.1155/2014/730472. Epub - 2014 Sep 9. PMID:25276131

Abstract and details.

The SOX Transcription Factors as Key Players in Pluripotent Stem Cells

Abdelalim EM1, Emara MM, Kolatkar PR.

Stem Cells Dev. 2014 Sep 26. [Epub ahead of print] PMID:25127330

Abstract and details.

Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by A disintegrin and metalloproteinase with thrombospondin motifs-15 (ADAMTS-15).

Kelwick R, Wagstaff L, Decock J, Roghi C, Cooley LS, Robinson SD, Arnold H, Gavrilović J, Jaworski DM, Yamamoto K, Nagase H, Seubert B, Krüger A, Edwards DR.

Int J Cancer. 2014 Aug 6. doi: 10.1002/ijc.29129. [Epub ahead of print] PMID:25099234

Abstract and details.

Influenza A Virus Host Shutoff Disables Antiviral Stress-Induced Translation Arrest

Denys A. Khaperskyy, Mohamed M. Emara, Benjamin P. Johnston, Paul Anderson, Todd F. Hatchette, Craig McCormick

PLoS Pathogens, July 10, 2014

Abstract and details.

New Proteomic Insights on the Role of NPR-A in Regulating Self-Renewal of Embryonic Stem Cells

Sameh Magdeldin, Tadashi Yamamoto, Ikuo Tooyama, Essam M. Abdelalim

Stem Cell Reviews and Reports . 2014; 10 (4), 561-572

Abstract and details.

Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue

Ali Tiss , Abdelkrim Khadir , Jehad Abubaker , Mohamed Abu-Farha , Irina Al-Khairi , Preethi Cherian , Jeena John , Sina Kavalakatt , Samia Warsame , Fahad Al-Ghimlas , Naser Elkum , Kazem Behbehani, Said Dermime and Mohammed Dehbi.

Lipids in Health and Disease. 2014; 13:106.

Abstract and details.

Structure of liganded T-state haemoglobin from cat (Felis silvestris catus ), a low oxygen-affinity species, in two different crystal forms

Moovarkumudalvan Balasubramanian, Ponnuraj Sathya Moorthy, Kamariah Neelagandan, Ramya Ramadoss, Prasanna R. Kolatkar and M. N. Ponnuswamy

Acta Cryst. 2014; D70:1898-1906.

Abstract and details.

Mutations in zinc finger 407 [ZNF407] cause a unique autosomal recessive cognitive impairment syndrome

Marios Kambouris, Rachid C Maroun, Tawfeg Ben-Omran, Yasser Al-Sarraj, Khaoula Errafii, Rehab Ali, Hala Boulos, Patrick A Curmi and Hatem El-Shanti

Orphanet Journal of Rare Diseases 2014; 9:80.

Abstract and details.

Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans

Baturcam E, Abubaker J, Tiss A, Abu-Farha M, Khadir A, Al-Ghimlas F, Al-Khairi I, Cherian P, Elkum N, Hammad M, John J, Kavalakatt S, Lehe C, Warsame S, Behbehani K, Dermime S & Dehbi M

Mediators Inflamm.2014:627150. doi: 10.1155/2014/627150.

Abstract and details.

IL -33 is negatively associated with the BMI and confers a protective lipid/metabolic profile in non-diabetic but not diabetic subjects.

Hasan A, Al-Ghimlas F, Warsame S, Al-Hubail A, Ahmad R, Bennakhi A, Al-Arouj M, Behbehani K, Dehbi M & Dermime S.

BMC Immunol. 2014 May 10;15(1):19.

Abstract and details.

Utilization of Gene Mapping and Candidate Gene Mutation Screening for Diagnosing Clinically Equivocal Conditions: A Norrie Disease Case Study.

Chini V, Stambouli D, Nedelea FM, Filipescu GA, Mina D, Kambouris M, El-Shanti H.

Eye Science. 2014 [In Press]

Abstract and details.

Pluripotent Stem Cells as a Potential Tool for Disease Modelling and Cell Therapy in Diabetes.

>Abdelalim EM, Bonnefond A., Annelise Bennaceur-Griscelli, Froguel P.

Stem Cell Reviews and Reports. 2014 Jun;10(3):327-37. doi: 10.1007/s12015-014-9503-6.

Abstract and details.

Knockdown of p53 suppresses Nanog expression in embryonic stem cells.

Abdelalim EM, Tooyama I.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):652-7. doi: 10.1016/j.bbrc.2013.12.030. Epub 2013 Dec 11.

Abstract and details.

Molecular Mechanisms Controlling the Cell Cycle in Embryonic Stem Cells.

Abdelalim EM.

Stem Cell Rev. 2013 Dec; 9(6):764-73. doi: 10.1007/s12015-013-9469-9

Abstract and details.

Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity.

Abu-Farha M, Tiss A, Abubaker J, Khadir A, Al-Ghimlas F, Al-Khairi I, Baturcam E, Cherian P, Elkum N, Hammad M, John J, Kavalakatt S, Warsame S, Behbehani K, Dermime S, Dehbi M.

PLoS One. 2013 Sep 24;8(9):e75342.

Abstract and details.

Exploiting human CD34+ stem cell-conditioned medium for tissue repair.

Mintz PJ, Huang KW, Reebye V, Nteliopoulos G, Lai HS, Sætrom P, Kasahara N, Jensen S, Madhava P, Gordon MY, Marley SB, Behan R, Spalding DR, Haoudi A, Emara MM, Nicholls J, Rossi JJ, Habib NA.

Molecular Therapy. 2013 Aug 28. doi: 10.1038/mt.2013.194. [Epub ahead of print]

Abstract and details.

Sox transcription factors require selective interactions with Oct4 and specific transactivation functions to mediate reprogramming.

Aksoy I, Jauch R, Eras V, Bin AC, Chen J, Divakar U, Ng CK, Kolatkar PR, Stanton LW.

Stem Cells. 2013 Aug 20. doi: 10.1002/stem.1522. [Epub ahead of print]

Abstract and details.

A novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo.

Reebye V, Saetrom P, Mintz PJ,… Emara MM, Haoudi A,… Spalding DR.

Hepatology. 2013 Aug 8. doi: 10.1002/hep.26669. [Epub ahead of print]

Abstract and details.

Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes.

Allen RE, Hughes TD, Ng JL, Ortiz RD, Ghantous MA, Bouhali O, Froguel P, Arredouani A.

Theoretical Biology and Medical Modelling. 2013 Jul 13; 10:45. doi: 10.1186/1742-4682-10-45.

Abstract and details.

What Makes a Pluripotency Reprogramming Factor?

Jauch R, Kolatkar PR.

Curr Mol Med. 2013 May 2. [Epub ahead of print]

Abstract and details.

MicroRNA-181a* Targets Nanog in a Subpopulation of CD34(+) Cells Isolated From Peripheral Blood.

Mintz PJ, Sætrom P, Reebye V, Lundbæk MB, Lao K, Rossi JJ, Gaensler KM, Kasahara N, Nicholls JP, Jensen S, Haoudi A, Emara MM, Gordon MY, Habib NA.

Mol Ther Nucleic Acids. 2012 Aug 7;1:e34. doi: 10.1038/mtna.2012.29

Abstract and details.

Hydrogen peroxide induces stress granule formation independent of eIF2a phosphorylation.

Emara MM, Fujimura K, Sciaranghella D, Ivanova V, Ivanov P, Anderson P.

Biochem Biophys Res Commun. 2012 Jul 13;423(4):763-9. doi: 10.1016/j.bbrc.2012.06.033. Epub 2012 Jun 15.

Abstract and details.

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